基于单个颈动脉压力波形获取主动脉脉搏波速度的可行性研究  

Feasibility study on aortic pulse wave velocity obtained from single carotid pressure waveform

作　　者：叶骏[1,2] 张永亮[1] 胡福松[1] 黎承涛[1,2] 吴庆园 马祖长[1] 孙怡宁[1] 

机构地区：[1]中国科学院合肥智能机械研究所,合肥230031 [2]安徽大学电子信息工程学院,合肥230039

出　　处：《北京生物医学工程》2016年第2期198-202,207,共6页Beijing Biomedical Engineering

基　　金：国家自然科学基金(61301059);国家科技支撑计划(2013BAH14F01)资助

摘　　要：目的评估基于单个颈动脉压力波形分解以获取主动脉脉搏波速度(aortic pulse wave velocity,ao PWV)的可行性,验证该方法是否适用于动脉硬化的早期筛查。方法研究对象为53名无明显心血管病的健康人群[男性22人,女性31人,(58.6±13.7)岁]。利用压力传感器同步获取颈动脉和股动脉脉搏波形,计算颈股动脉脉搏波传导时间(carotid-femoral pulse transit time,cf PTT)和传导速度(carotid-femoral pulse wave velocity,cf PWV)。利用阻抗分析技术将颈动脉压力波形分解为前向波和反向波。通过对前向波和反向波进行相关分析获得主动脉脉搏波传导时间(aortic pulse transit time,ao PTT)和传导速度(aortic pulse wave velocity ao PWV)。评估ao PTT与cf PTT以及ao PWV与cf PWV之间的相关性和一致性。结果基于单个颈动脉压力波形分解获得的ao PTT与实测的cf PTT显著相关(r=0.624,P<0.001),组内相关系数为0.621;ao PWV与cf PWV之间的相关系数为0.476(P<0.001),组内相关系数等于0.452。老年人(年龄≥60岁,29人)ao PWV与cf PWV间的相关性显著低于中青年人(0.267 vs 0.549,P<0.001)。结论基于单个颈动脉压力波形分解获取ao PWV与实测的cf PWV之间只具有中度的相关性和一致性,且在老年人中相关性更低。该方法可能不适用于老年人的ao PWV检测。Objective This paper evaluated the feasibility of aortic pulse wave velocity（ ao PWV）obtained from the decomposition of single carotid pressure waveform and judged whether the method was suitable for early screening of arterial stiffness. Methods The subjects were 53 healthy people [22 men and 31 women,mean age：（ 58. 6 ± 13. 7） years] who were free from cardiovascular diseases. Carotid and femoral pulse waveforms obtained simultaneously by pressure sensors were used to calculate carotid-femoral pulse transit time（ cf PTT） and carotid-femoral pulse wave velocity（ cf PWV）. Carotid pressure waveform was decomposed into forward and backward waves through impedance analysis.Aortic pulse transit time（ ao PTT） and aortic pulse wave velocity（ ao PWV） were determined from cross-correlation of forward and backward waves. The correlation and consistency between ao PTT and cf PTT and those between ao PWV and cf PWV were evaluated. Results ao PTT obtained by decomposition of single carotid pressure waveformsignificantly correlated to measured cf PTT（ r = 0. 624,P 〈 0. 001）,intraclass correlation coefficient was0. 621. The correlation coefficient between ao PWV and cf PWV was 0. 476（ P 〈 0. 001）,intraclass correlation coefficient was 0. 452. The correlation between ao PWV and cf PWV of older people（ age ≥60 years,29 people）was significantly lower than that of young and middle-aged people（ 0. 267 vs 0. 549,P 〈 0. 001）. Conclusions There is only moderate correlation and consistency between ao PWV obtained by decomposition of single carotid pressure waveform and measured cf PWV,and the correlation is lower in older people group. Decomposition of single carotid pressure waveform may not be suitable for measurement of ao PWV in older people.

关 键 词：颈动脉 主动脉脉搏波速度 波形分析 老年人 

分 类 号：R318.04[医药卫生—生物医学工程]