辽宁省一般人群全血中铜和锌水平分布的研究  

Investigation of copper and zinc levels in blood of general population in Liaoning province

作　　者：田昊渊[1] 张云江[2] 张瑶瑶[3] 魏明智[3] 王凯[3] 郑晓梅[3] 庞妍[3] 何杨[3] 张蕴丽[4] 潘兴富[1] 闫慧芳[1] 郑玉新[1] 彭珊茁[3] 

机构地区：[1]中国疾病预防控制中心职业卫生与中毒控制所化学污染与健康安全重点实验室,北京100050 [2]丹东市疾病预防控制中心 [3]沈阳市劳动卫生职业病研究所检验科 [4]辽宁医学院附属医院检验科

出　　处：《环境与健康杂志》2016年第1期37-40,共4页Journal of Environment and Health

基　　金：卫生部卫生公益性行业科研专项(200802020);国家科技支撑计划项目(2006BAI06B02);沈阳市科学计划项目(1091165-9-00)

摘　　要：目的了解辽宁省一般人群血中铜、锌水平的分布,并分析其分布特点。方法采用整群随机抽样的方法,于2009—2010年在辽宁省东、中、西部3个城市的区县中,抽取了2 105名6-60岁人群作为调查对象,进行问卷调查及血液样品采集。应用电感耦合等离子体质谱法检测样品中铜、锌水平,分析探讨在不同性别、年龄、地区以及生活方式中铜、锌水平分布情况。结果调查对象血铜几何均数为783μg/L,95%CI为775-791μg/L,P5、P50和P95分别为555、785和1 059μg/L。男性血铜几何均数（778μg/L）低于女性（788μg/L）（P〈0.01）。不同年龄组人群血铜几何均数差异有统计学意义（P〈0.01）,其中6-12岁年龄组血铜最高（为853μg/L）,13-16岁年龄组血铜最低（为649μg/L）;辽宁省东、中、西部地区人群血铜几何均数分别为706、852和837μg/L,差异有统计学意义（P〈0.01）;在吸烟与饮酒特征中人群血铜几何均数差异均无统计学意义（P〉0.05）。调查对象血锌几何均数为4 158μg/L,95%CI为4 115-4 201μg/L,P5、P50和P95分别为2 657、4 243和5 931μg/L。男性血锌几何均数（4 258μg/L）显著高于女性（4 058μg/L）（P〈0.01）;不同年龄组人群血锌几何均数差异具有统计学意义（P〈0.01）,其中,6-12岁年龄组血锌最低（为3 574μg/L）,31-45岁年龄组血锌最高（为4 593μg/L）;辽宁省东、中、西部地区人群血锌几何均数分别为4 315、3 811和4 286μg/L,差异有统计学意义（P〈0.01）;吸烟和饮酒人群血锌高于不吸烟、不饮酒人群,差异均有统计学意义（P〈0.01）。辽宁省一般人群血铜几何均数（783μg/L）低于全国一般人群血铜（795μg/L）（P〈0.01）。辽宁省一般人群血锌几何均数（4 158μg/L）高于全国一般人群血锌（3 996μg/L）（P〈0.01）。结论辽宁省一般人群血液中铜、锌水平在不同性别、年龄、区域特征中均存在差异。辽宁省一般人�Objective To know the blood copper（Cu） and zinc（Zn） levels of the general population in Liaoning province.Methods From 2009 to 2010,2105 subjects aged 6-60 years were recruited from three cities in east,centre and west area of Liaoning province,by cluster random sampling method. Inductive coupled plasma mass spectrometry（ICP-MS） was applied to analyze the levels of Cu and Zn in blood samples. The background information of the subjects was collected by questionnaires.The levels of Cu and Zn were analyzed statistically for gender,age,city and life-style. Results The geometric mean（GM） of Cu levels in blood（95%CI） was 783（775-791） μg/L,P5, P50 and P95were 555, 785 and 1 059 μg/L respectively. The GM of blood Cu levels in male（778 μg/L） was significantly lower than that in female（788 μg/L）（P 0.01）. There was a significant age specific difference in GM of blood Cu levels（P〈0.01）, the highest blood Cu levels were in 6-12 age group（853 μg/L）, the lowest blood Cu levels were in 13-16 age group（649 μg/L）. The GM of Cu levels in east,centre and west area were 706,852 and 837 μg/L respectively（P〈0.01）. There was no statistical difference in the GM of blood Cu levels among smoker or drinker（P0.05）. The GM of Zn levels in blood（95%CI） were 4 158（4 115-4 201） μg/L,P5, P50 and P95were 2 657, 4 243 and 5 931μg/L, respectively. The GM of blood Zn levels in male（4 258 μg/L） was significantly higher than that in female（4 058 μg/L）（P〈0.01）. There was a statistical difference in the GM of blood Zn levels among age groups（P〈0.01）, the lowest were in 6-12 age group（3 574 μg/L）, the highest were in 31-45 age group（4 593 μg/L）. The GM of Zn levels in eastern,centre and west area were 4 315,3 811 and 4 286 μg/L（P〈0.01）. The levels of blood Zn levels were significant higher among smoker and drinker（P〈0.01）. Conclusion The concentrations and distributions of Cu and Zn levels in blood of general people in Liaoning provinc

关 键 词：铜 锌 全血 辽宁 一般人群 

分 类 号：R181.3[医药卫生—流行病学]