二仙汤对卵巢早衰免疫指标影响的临床观察  

Clinical observation on effect of Erxian decoction on immune indexes of premature ovarian failure

作　　者：吕晓琳[1] 艾浩[1] 

机构地区：[1]辽宁医学院附属第一医院妇产科,辽宁锦州121000

出　　处：《中国妇幼保健》2016年第9期1811-1813,共3页Maternal and Child Health Care of China

基　　金：2011年国家自然科学基金项目(81173443)

摘　　要：目的探讨二仙汤治疗免疫性卵巢早衰患者的临床疗效。方法选择2012年10月-2014年2月在辽宁医学院附属第一医院就诊的自身免疫性卵巢早衰患者60例,按治疗方式分为激素组(A组)30例和二仙汤组(B组)30例。A组患者服用雌激素片和醋酸甲羟孕酮片,B组服用水煎二仙汤,观察两组患者的临床疗效,比较两组患者治疗后月经周期、血清内激素水平和相关抗体水平以及T淋巴细胞亚群。结果二仙汤组患者月经周期和综合疗效与激素组患者相比差异无统计学意义(P>0.05),二仙汤组患者的FSH、AOab、AZpAb和T淋巴细胞标志(CD4、CD8)改善效果比激素组患者好,差异有统计学意义(P<0.05)。结论二仙汤治疗免疫性卵巢早衰患者效果显著,复发率低,但是其具体机制需要深入研究。Objective To explore the clinical effect of Erxian decoction in treatment of autoimmune premature ovarian failure.Methods Sixty patients with autoimmune premature ovarian failure treated in the hospital from October 2012 to February 2014 were selected and randomly divided into hormone group（ A group,30 cases） and Erxian decoction group（ B group,30 cases）. The patients in A group were treated with estrogen tablets and medroxyprogesterone acetate tablets,while the patients in B group were treated with Erxian decoction.The clinical effects in the two groups were observed; the menstrual cycles,serum hormone levels,related antibodies levels,T lymphocyte sbusets after treatment in the two groups were compared. Results There was no statistically significant difference in menstrual cycle and comprehensive effect between the two groups（ P〉0. 05）; the improvement effects of FSH,Ao Ab,AzpAb,and T cells markers（ CD4,CD8） in B group were statistically significantly better than those in A group（ P〈0. 05）. Conclusion The therapeutic effect of Erxian decoction in treatment of patients with autoimmune premature ovarian failure is significant with low recurrence rate,but the mechanism need to be further investigated.

关 键 词：卵巢早衰 二仙汤 激素 免疫 

分 类 号：R711.75[医药卫生—妇产科学]