男性2型糖尿病一级亲与非一级亲基线血尿酸水平与冠状动脉病变的前瞻性比较  

A prospective comparison cohort study between baseline serum uric acid level and coronary artery disease in first-degree relatives and non-first-degree relatives of type 2 diabetes males

作　　者：麻秀娟[1] 王海丽[2] 于桂芝[3] 焦秀华[4] 郝凤杰[1] 蔡丽静[1] 张宗群[5] 

机构地区：[1]承德市中心医院内分泌科,067000 [2]承德市中心医院超声诊断科,067000 [3]承德市中心医院放化疗科,067000 [4]承德市中心医院肾内科科,067000 [5]承德市中心医院神经内科,067000

出　　处：《中华内分泌代谢杂志》2016年第4期277-280,共4页Chinese Journal of Endocrinology and Metabolism

摘　　要：目的探讨男性2型糖尿病一级亲和非一级亲患者基线血尿酸水平与冠状动脉病变的关系。方法纳入首次冠脉造影检查病变为阴性的男性有效病例381例，据血糖分为糖尿病组及血糖正常组。随访5年，再次发生急性冠脉综合征为终点事件并复查冠脉造影。应用冠脉狭窄指数（CSI）及冠脉病变支数评价冠脉病变程度。结果血糖正常组，糖尿病一级亲的基线血尿酸水平显著高于非一级亲组（P〈0．01）；冠状动脉病变患病率、CSI及多支冠状动脉病变患病率皆明显升高（P〈0．01）；相关分析显示其CSI（r=0．250，JP=0．041）和冠状动脉病变患病率（r=0．252，P=0．040）与基线血尿酸水平存在相关性。结论基线血尿酸水平与冠脉病变的发生有密切联系．对于血糖正常男性2型糖尿病一级亲患者这一特征表现尤为明显。因此，基线血尿酸水平可以作为冠状动脉病变发生的早期预测指标。Objective To investigate the relationship between baseline serum uric acid and the severity of coronary artery disease （CAD） in the first-degree relatives or non-first-degree relatives of men with type 2 diabetes. Methods Three hundred and eighty-one men with negative coronary angiography for the first time were divided into diabetes and non-diabetes groups and followed-up for 5 years. The primary outcome was acute coronary syndrome suspected during subsequent 5 years, and the coronary angiography was conducted simultaneously. The severity of CAD was assessed by the coronary stenosis index （CSI） and the number of coronary lesion vessels. Results In normal blood glucose group, serum uric acid was higher in the first-degree relatives of diabetics compared with non- first-degree relatives （P〈0.01）, along with higher morbidity of CAD, CSI, and coronary lesion vessels （ all P〈 0.01 ）. Correlation analysis showed that CSI （ r = 0. 250, P = 0. 041 ） and coronary lesion vessels （ r = 0. 252, P = 0.040）in non-diabetics group were associated with baseline levels of serum uric acid. Conclusion The elevation of serum uric acid was closely related to subsequent CAD, especially in first-degree relatives of male with type 2 diabetes, which could be used as an early indicator for CAD prediction.

关 键 词：前瞻性 血尿酸 糖尿病 2型 一级亲 冠状动脉疾病 

分 类 号：R587.1[医药卫生—内分泌] R541.4[医药卫生—内科学]