血小板参数及活化标志物与2型糖尿病患者颈动脉内膜中层厚度的相关性  

Correlation of carotid intima-media thickness with platelet parameters and markers of platelet activation in patients with type 2 diabetes mellitus

作　　者：曲云霄[1] 蒋知新 韩腾龙 王丽丽 高德禄 

机构地区：[1]南方医科大学研究生学院,广州市510515 [2]解放军305医院中心实验室,北京市100017

出　　处：《实用医学杂志》2016年第8期1250-1253,共4页The Journal of Practical Medicine

基　　金：军队"十二五"医药卫生基金项目资助课题(编号:2013XL010)

摘　　要：目的:探讨血小板参数及活化标志物与2型糖尿病患者颈动脉内膜中层厚度(CIMT)的相关性。方法:收集2型糖尿病住院患者共195例,根据颈动脉内膜中层厚度分为无病变组60例,增厚组50例,斑块组85例,测定3组患者血小板数量(PLT)、平均血小板体积(MPV)、血小板分布宽度(PDW)、血小板容积(PCT)、空腹血糖(GLU)、总胆固醇(TC)等指标及尿液11-DH-TXB2的含量,并进行统计学分析。结果:(1)斑块组患者病程、LDL-C、MPV、PDW、11-DH-TXB2水平高于无病变组及CIMT增厚组(P<0.05);(2)CIMT增厚组患者病程、LDL-C、MPV、PDW、11-DH-TXB2水平高于无病变组(P<0.05);(3)Spearman相关分析显示CIMT与年龄、病程、BMI、GLU、GHb A1C、LDL-C、MPV、PDW及11-DH-TXB2水平呈正相关,与HDL-C、PLT水平呈负相关(P<0.05);(4)Logistic回归分析显示MPV、PDW和11-DH-TXB2是2型糖尿病患者CIMT异常的危险因素。结论:血小板参数(MPV、PDW)及活化标志物(尿11-DH-TXB2)与2型糖尿病患者颈动脉内膜中层厚度具有相关性。Objective To observe the correlation between platelet parameters,platelet activation marker and carotid intima-media thickness（CIMT） in patients with type 2 diabetes mellitus.Methods One hundred and ninety-five type 2 diabetic patients were enrolled in this study.The patients were divided into the normal control group,the CIMT increased group and the clot group according to the carotid intima-media thickness.Levels of platelet count（PLT）,mean platelet volume（MPV）,platelet distribution width（PDW）,platelet hematocrit（PCT）,urinary 11-dehydro-thromboxane B2（11-DH-TXB2） and other clinical,biochemical characteristics were measured.Results（1） Levels of serum LDL-C,MPV,PDW,urinary 11-DH-TXB2 and clinical course in the clot group were higher than those in the CIMT increased group and the normal control group（P〈0.05）.（2） Compared with the normal control group,the clinical course,serum LDL-C,MPV,PDW and urinary 11-DH-TXB2 were higher in the CIMT increased group（P〈0.05）.（3） By using with spearman rank correlation test,carotid intima-media thickness was positively associated with age,course,BMI,GLU,GHb A1 C,LDL-C,MPV,PDW and urinary11-DH-TXB2,whereas carotid intima-media thickness was negative associated with HDL-C,PLT（both P〈0.05）.（4） MPV,PDW and urinary11-DH-TXB2 were shown as the independent risk factors for CIMT.Conclusions Platelet activation marker and platelet parameters are associated with carotid intima-media thickness in patients with type 2 diabetes mellitus.

关 键 词：糖尿病 2型 血小板参数 尿液11-脱氢血栓素B2 颈动脉内膜中层厚度 

分 类 号：R587.2[医药卫生—内分泌]