糖尿病性视网膜病变以及黄斑水肿和黄斑中心凹下脉络膜厚度的关系  

The relationship between the macular edema and the thickness of macular subfoveal choroid in diabetic retinopathy patients

作　　者：唐晓娟[1] 刘琼[1] 于健[1] 丁媛媛[1] 吴京[1] 

机构地区：[1]南方医科大学南方医院眼科,510515

出　　处：《实用医学杂志》2016年第8期1302-1305,共4页The Journal of Practical Medicine

基　　金：广东省自然科学基金(编号:S2012010008946;S2013010016640)

摘　　要：目的:观察糖尿病性视网膜病变(diabetic retinopathy,DR)以及其是否存在黄斑水肿(diabetic macular edema,DME)和黄斑中心凹下脉络膜厚度(subfoveal choroidal thickness,SFCT)的关系。方法:纳入已确诊糖尿病患者70例122只眼。其中男36例64只眼,女34例58只眼,平均年龄(56.7±9.7)岁。所有患者均行必要眼科检查。分组:无DR(no diabetic retinopathy,NDR)组、轻度至中度非增生型DR(轻中度NPDR)组、重度非增生型DR(重度NPDR)组、增生型DR(proliferative diabetic retinopathy,PDR)组。后三组又分为伴有和不伴有显著性黄斑囊样水肿(clinical significant macular edema,CSME)两个亚组(CSME+/CSME-)。应用Sn OCT深度增强成像技术(EDI)测量受检者SFCT,应用SPSS 17.0软件统计分析。结果:NDR组、轻中度NPDR组、重度NPDR组、PDR组SFCT分别为(282.94±104.21)、(313.62±94.40)、(382.44±76.91)、(335.00±73.82)μm,NDR组SFCT比其他三组薄,差异有统计学意义(F=2.786,P=0.03)。轻中度NPDR/CSME-组与轻中度NPDR/CSME+组、重度NPDR/CSME-组与重度NPDR/CSME+组、PDR/CSME-组与PDR/CSME+组SFCT比较差异均无统计学意义。结论:DR患者的SFCT随视网膜病变程度加重增厚;视网膜病变程度相同情况下,CSME+与CSME-患者SFCT无明显差异。Objective To evaluate the relationship between the existence of DME and the SFCT in DR patients.Methods We collected 70 cases which were clinical diabetic involving 122 eyes.They are 36 men with 64 eyes and 34 women with 58 eyes.The average age is 56.7 ± 9.7 year-old.All patients had been examined by ophthalmologic examination.Grouping：patients without diabetic retinopathy（NDR） group;mild-to-moderate NPDR group;severe NPDR group;PDR group.The last three groups were divided into two subgroup groupsrespectively,which were cases with and without significant macular edema（CSME ＋ / CSME）.EDI was used to measure the SFCT.SPSS 17.0 software was used for statistical analysis.Results The average SFCT of NDR group,mild-tomoderate NPDR group,severe NPDR group and the PDR group respectively were（282.94 ± 104.21）μm,（313.62± 94.40）μm,（382.44 ± 76.91）μm,（335.00 ± 73.82）μm.Compared with the NDR group,SFCT was thicker than the other three groups,and difference was statistically significant（F = 2.786,P = 2.786）.There were no statistically significant difference of SFCT between the mild-to-moderate NPDR / CSME-group and mild-to-moderate NPDR / CSME ＋ group,severe NPDR / CSME-group and severe NPDR / CSME ＋ group PDR / CSME-group,PDR /CSME ＋ group.Conclusions The SFCT of DR patients could potentially be thickenedas disease became serious.When considered the same degree DR,there is no obvious difference of SFCT between patients with CSME and without CSME.

关 键 词：糖尿病性视网膜病变 黄斑水肿 脉络膜 光学相干断层扫 

分 类 号：R587.2[医药卫生—内分泌]