Effects of two efflux pump inhibitors on the drug susceptibility of Riemerella anatipestifer isolates from China  

作　　者：LI Ya-fei JIANG Hong-xia XIANG Rong SUN Na ZHANG Ya-nan ZHAO Li-qing GU Peng WANG Li-qiao ZENG Zhen-ling 

机构地区：[1]Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, South China Agricultural University [2]Institute of Animal Healthy, Guangdong Academy of Agricultural Sciences,Guangdong Open Laboratory of Veterinary Public Health [3]Institute of Special Animal and Plant Sciences, Chinese Academic of Agricultural Sciences

出　　处：《Journal of Integrative Agriculture》2016年第4期929-933,共5页农业科学学报（英文版）

基　　金：supported by the Program for Changjiang Scholars and Innovative Research Team in University of Ministry of Education of China (IRT13063);the National Natural Science Foundation of China (31072169)

摘　　要：The objective of this study was to verify the supposition that efflux might be involved in the drug resistance of Riemerella anatipestifer isolates. Two broad-spectrum effiux pump inhibitors, carbonyl cyanide 3-chlorophenylhydrazone （CCCP） and Phe-Arg-β-naphthylamide （PAL3N）, on the contribution of minimum inhibitory concentrations of amikacin, streptomycin, chloramphenicol, tetracycline, ceftdaxone, ceftazidime, nalidixic acid, levofloxacin, enrofloxacin, as well as ciprofloxacin against 69 clinical R. anatipestifer isolates were investigated. We first reported that the two efflux pump inhibitors could restore the antimicrobial susceptibility of R. anatipestiferisolates. It is suggested that active efflux system is possible to be linked with the development of resistance in R. anatipestifer isolates.The objective of this study was to verify the supposition that efflux might be involved in the drug resistance of Riemerella anatipestifer isolates. Two broad-spectrum effiux pump inhibitors, carbonyl cyanide 3-chlorophenylhydrazone （CCCP） and Phe-Arg-β-naphthylamide （PAL3N）, on the contribution of minimum inhibitory concentrations of amikacin, streptomycin, chloramphenicol, tetracycline, ceftdaxone, ceftazidime, nalidixic acid, levofloxacin, enrofloxacin, as well as ciprofloxacin against 69 clinical R. anatipestifer isolates were investigated. We first reported that the two efflux pump inhibitors could restore the antimicrobial susceptibility of R. anatipestiferisolates. It is suggested that active efflux system is possible to be linked with the development of resistance in R. anatipestifer isolates.

关 键 词：Riemerella anatipestifer RESISTANCE EFFLUX CCCP PAI3N 

分 类 号：S852.61[农业科学—基础兽医学]