新生儿败血症的临床特征、病原菌分布及耐药特点分析  

Clinical characteristics,pathogenic bacteria distribution and antibiotic resistance of neonatal septicemia

作　　者：徐艳[1] 由军[1] 毛春梅[1] 刘丽晓[1] 

机构地区：[1]哈尔滨医科大学附属第四医院儿科,黑龙江哈尔滨150001

出　　处：《哈尔滨医科大学学报》2016年第2期156-158,161,共4页Journal of Harbin Medical University

摘　　要：目的了解新生儿败血症的临床特征、病原菌分布及耐药特点。方法对16例住院患儿血培养阳性病例进行回顾性分析。结果 16例病例中病理性黄疸7例,早产儿5例,新生儿肺炎、新生儿脐炎、新生儿脓疱病及足月小样儿各1例;共检出17株细菌(G^+菌9株,G^-菌8株),1株真菌;革兰阳性菌以表皮葡萄球菌及溶血葡萄球菌为主,均为多重耐药菌,对万古霉素均敏感;革兰阴性菌多为敏感菌,部分对青霉素耐药,但对头孢类及碳青霉烯类均敏感。结论本院新生儿败血症多见于早产儿和病理性黄疸患儿;病原菌中G^+菌对抗生素耐药性强,G^-菌多较敏感。Objective To study the clinical features,pathogenic bacteria distribution and drug resistance characteristics of neonatal septicemia. Methods Sixteen cases of hospitalized children with blood culture positive were retrospectively analyzed. Results Among them,7 cases were pathological jaundice,5 cases were premature,neonatal pneumonia,neonatal omphalitis,neonates impetigo and small-for-date infant like each 1 case; 17 strains of bacteria（ G＋bacteria 9 strains,G-8 strains） and 1 strains of fungi were found; Gram-positive bacteria was given priority to with epidermis staphylococcus and hemolytic staphylococci,they were multiple drug-resistant bacteria,but were sensitive to vancomycin; most of gram negative bacteria were sensitive bacteria,some resistant to penicillin,but were sensitive to cephalosporins and penicillium carbon alkene antibiotics. Conclusion Neonatal sepsis is more common in preterm infants and children with pathological jaundice; the antibiotic resistance of pathogenic bacteria in G＋is strong,G-bacterium are more sensitive.

关 键 词：败血症 新生儿 致病菌 

分 类 号：R722[医药卫生—儿科]