布鲁氏菌逃逸宿主的抗感染免疫机制  

Evasion of anti-infectious immunity by Brucella- A review

作　　者：权伍荣[1] 杨咏洁[1] 

机构地区：[1]延边大学农学院,吉林延吉133002

出　　处：《微生物学报》2016年第5期747-752,共6页Acta Microbiologica Sinica

摘　　要：布鲁氏菌病是由布鲁氏菌引发的世界范围的人兽共患传染病。布鲁氏菌为兼性胞内寄生菌,无典型的毒力因子,但却有很强的致病性,常引发人和动物的慢性感染。逃逸宿主的抗感染免疫反应是慢性感染的先决条件,这种能力对于布鲁氏菌的毒力来说似乎也越来越关键。作为成功的致病性病原菌,布鲁氏菌采用"隐秘的"策略以逃避或抑制固有免疫、调节适应性免疫,从而在宿主细胞内建立长期的持续性感染。本文将围绕布鲁氏菌逃逸宿主的抗感染免疫的分子机制进行阐述,旨为阐明布鲁氏菌毒力的新见解,这很可能为布病的预防开辟新的途径。Brucellosis, caused by Brucella species, is a worldwide zoonosis. As facultative intracellular pathogens,Brucella possess non-classical virulence factor, but its virulence is very powerful and can elicit chronic infections of both animals and humans. Evasion of host anti-infectious immunity is a prerequisite for chronic infections, this ability appears increasingly crucial for Brucella virulence. As successful pathogens, Brucella can escape or suppress innate immunity and modulate adaptive immunity to establish long lasting infections in host cells. In this review, we address the molecular mechanisms of Brucella to evade anti-infectious immunity. This will shed new insights on Brucella virulence and will, potentially, open new prophylactic avenues.

关 键 词：布鲁氏菌 固有免疫 适应性免疫 逃逸 

分 类 号：Q939.91[生物学—微生物学]