恩替卡韦联合安络化纤丸治疗HBeAg阳性慢性乙型肝炎肝纤维化134例  

The therapy of entecavir combined with Anluo Huaxian capsule on HBeAg positive chronic hepatitis B-related liver fibrosis in 134 cases

作　　者：黄志杰[1] 曾翠萍[2] 

机构地区：[1]福建省泉州市解放军第180医院肝病中心,福建泉州362000 [2]福建省泉州市解放军第180医院肝胆外科

出　　处：《中西医结合肝病杂志》2016年第2期74-75,共2页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

摘　　要：目的:观察恩替卡韦(ETV)联合安络化纤丸治疗慢性乙型肝炎(CHB)肝纤维化的临床疗效。方法:134例CHB肝纤维化患者按照随机数字表法分为对照组(66例)和研究组(68例),对照组患者单服恩替卡韦,0.5mg/次,1次/d;研究组患者在对照组基础上加服安络化纤丸,6g/次,2次/d,两组疗程均为48周。比较治疗前后两组患者的肝功能(ALT、、AST、TBil)、肝纤维化4项指标HA、LN、PCIII、Ⅳ-C、脾厚度变化,以及治疗48周时两组患者HBV DNA和HBeAg转阴率情况。结果:治疗48周后,两组患者肝功能指标、肝纤维化4项及脾厚度均较治疗前明显下降,且研究组下降更为显著(P<0.05);研究组患者HBV DNA转阴率较对照组明显提升(P<0.05)。结论:恩替卡韦联合安络化纤丸能够显著改善CHB肝纤维化患者的肝功能,促进HBV DNA转阴,减缓肝纤维化进程。Objective：To observe the clinical efficacy of entecavir combined with Anluo Huaxian capsule onHBeAg positive chronic hepatitis B-related liver fibrosis.Methods.-One hundred and thirty four cases of chronic hepatitis B-related liver fibrosis patients were randomly divided into the control group（66 cases） and the study group（68 cases）.The control group were treated with entecavir（0.5mg,q.d.） only,while the study group were treatedwith Anluo Huaxian capsule（6g,b.d） on the basis of control group.Both groups were treated for 48 weeks.Compared the changes of liver function（ALT,AST.TBiL）,four indexes of hepatic fibrosis（HA,LN,PCIII,IV-C）,the spleen thickness of the two groups before and after treatment and compare the negative conversion ratio of HBVDNA and HBeAg of the two groups after 48 weeks＇ treatment.Results：After 48 weeks＇ treatment,the level of liver function,four indexes of hepatic fibrosis and the spleen thickness of both groups were all significantly declined than before and the study group were more significant（P〈0.05）.While the negative conversion ratio of HBVDNA in the study group was significantly improved compared with the control group（P〈0.05）.Conclusion：The therapy of entecavir combined with Anluo Huaxian capsulecould significantly improve the liver function,promote HBV DNA conversion and reverse process for chronic hepatitis B-related liver fibrosis patients.

关 键 词：肝炎 乙型 慢性 肝纤维化 恩替卡韦/临床应用 安络化纤丸/临床应用 

分 类 号：R512.62[医药卫生—内科学]