胆囊结石合并2型糖尿病患者血胆囊收缩素受体表达的相关性研究  

The correlation of CCK receptors in gallstones patients with type 2 diabetes mellitus

作　　者：王胜[1] 李宏宇[2] 李波[2] 魏永刚[2] 

机构地区：[1]宁夏银川市第一人民医院,宁夏银川750001 [2]四川大学华西医院肝脏外科,四川成都610041

出　　处：《宁夏医学杂志》2016年第4期299-301,共3页Ningxia Medical Journal

摘　　要：目的探讨胆囊结石合并2型糖尿病患者血胆囊收缩素(CCK)受体的表达水平。方法 26例胆囊结石合并2型糖尿病患者(观察组)和24例单纯胆囊结石患者(对照组)纳入回顾性研究。用彩超评估患者胆囊排空功能、免疫放射配体结合试验测定CCK受体活性。结果观察组患者胆囊排空体积(11.6±5.1)m L和胆囊排空分数(17.2±11.3)%明显低于对照组患者的(21.5±7.8)m L和(52.8±12.9)%;观察组患者血CCK受体定量及CCK受体活性也明显低于对照组患者。结论胆囊结石合并Ⅱ型糖尿病患者血CCK受体表达明显降低,导致此类患者胆囊排空延迟,易于形成胆囊结石。Objective To investigate the expression of CCK receptors in patients with gallbladder stones and T2 DM. Methods 26 patients with gallstones and T2DM（ Group 1） and 24 gallstones patients without T2DM（ Group 2） were enrolled in this study. The emptying function of the gallbladder was measured by ultrasonography. The activity of CCK- R was analyzed by radioligand method. Results Gallbladder ejection volume（ EV）（ 11. 6 ± 5. 1） m L /（ 21. 5 ± 7. 8） m L and gallbladder ejection fraction（ GBEF2）（ 17. 2 ± 11. 3） m L /（ 52. 8 ± 12. 9）m L were significantly lower in patients with gallstones and T2DM（ P〈0. 05）. The amount of CCK- R and the activity of CCK- R in group1 were significantly lower than that in group 2（ P〈0. 05）. Conclusion The expression of CCK- R in gallstones patients with T2 DM is much lower in such patients,which is impairing gallbladder emptying function and the formation of gallstones.

关 键 词：胆囊收缩素 胆囊结石 2型糖尿病 

分 类 号：R587.1[医药卫生—内分泌] R575.62[医药卫生—内科学]