血液中18种常见毒物的气相色谱-质谱同时检测  

Simultaneous determination of 18 toxicants and drugs in blood by gas chromatography-mass spectrometry method

作　　者：石银涛[1] 王俊伟[1] 郭璟琦[1] 郭浩[1] 宋胜利[2] 郑经[1] 

机构地区：[1]重庆市公安局物证鉴定中心,重庆400021 [2]广州市公安局花都区分局刑警大队,广州510800

出　　处：《分析试验室》2016年第4期443-447,共5页Chinese Journal of Analysis Laboratory

基　　金：重庆市公安局科技攻关计划项目(G2013-04)资助

摘　　要：建立了血液中18种常见毒物的气相色谱-质谱（GC-MS）同时检测方法。血液中目标物经液液提取,浓缩至干后,用甲醇溶解残渣,采用GC-MS进行测定,外标法定量。目标物的线性范围为2~20μg/m L,相关系数为0.9914~0.9991,检出限为0.02~1μg/m L。在2,5,10μg/m L 3个浓度添加水平的平均回收率为53.8%~91.2%,相对标准偏差为3.8%~6.1%。方法可用于法庭与临床血液样品中的毒物分析。A method has been developed for simultaneous determination of 18 toxicants and drugs in blood by gas chromatography-mass spectrometry（ GC-MS）. The samples were extracted by liquid-liquid extraction（ LLE）.The extract was concentrated to try,dissolved in methanol and analyzed by GC-MS with external standard. Good linearities were observed in the range of 2 ~ 20 μg / m L with the correlation coefficients from 0. 9914 to 0. 9991.The limits of detection were 0. 02 ~ 1. 0 μg / m L. The spiked recoveries were 53. 8% ~ 91. 2% with the relative standard deviations of 3. 8% ~ 6. 1%. The developed method was rapid,simple,effective,sensitive,and suitable for the simultaneous determination of toxicants and drugs in forensic and clinical blood samples.

关 键 词：气相色谱-质谱联用仪 毒物 血液 同时测定 

分 类 号：O657.63[理学—分析化学]