胱抑素C与慢性充血性心力衰竭近期预后的关系  

The Relationship Between Cystatin-C and Immediate Prognosis of Chronic Congestive Heart Failure

作　　者：石运生[1] 张利民[1] 董茂盛[1] 李妍辰[1] 贾关亮 张波[1] 常美丽[1] 

机构地区：[1]内蒙古包头市第八医院心血管内科,内蒙古包头014000

出　　处：《标记免疫分析与临床》2016年第4期389-391,394,共4页Labeled Immunoassays and Clinical Medicine

摘　　要：目的通过检测慢性充血性心力衰竭患者胱抑素C(Cys-C)血清浓度,观察Cys-C与慢性心衰患者心功能的关系,探讨Cys-C浓度与慢性心衰患者近期预后的关系。方法选择我院2014年1月至2015年6月期间的心脏病患者共555例,心功能I级者150例作为对照组,心功能II级200例,III级150例,IV级55例。入院后24小时内空腹静脉血检测Cys-C、脑钠肽(BNP)血清浓度。分析比较不同心功能分级组Cys-C的测值,观察心衰患者Cys-C与脑钠肽(BNP)的相关性。出院后随访3个月,随访终点包括心力衰竭复发或心源性死亡。结果 1心衰患者Cys-C血清浓度均增高,并且心衰越严重患者Cys-C升高越明显,组间比较,差异有统计学意义(P<0.05)。2相关分析显示血清胱抑素C浓度与BNP呈正相关(rs=0.734,P<0.05)。随访患者心衰复发率及心源性死亡率Cys-C增高组与Cys-C正常组比较明显增高,差异有统计学意义(P<0.05)。结论心衰患者Cys-C血清浓度与心衰严重程度呈正相关,高Cys-C患者存在早期的肾损害,近期心衰复发率及心源性死亡率明显高于Cys-C正常患者,Cys-C是评估心力衰竭患者近期预后极有意义的指标。Objective To observe the relationship between Cystatin-C（ Cys-C） and chronic congestive heart failure and to explore the correlation between the concentration of Cys-C and immediateprognosis of chronic congestive heart failure. Methods 555 patients with heart disease were recruited during the period of Jan. 2014 to June 2014 in our hospital. The control group was composed of 150 cases with heart function I level. There were 200 cases with heart function II level,150 cases with heart function III level and 55 cases with heart function IV level. Fasting vein blood Cys-C,BNP were tested within 24 h after admission. Cys-C value among the different groups and the correlation between Cys-C and BNP were analyzed by SPSS 16. 0 version. Following up for 3 months post-discharge and following end point included heart failure recurrence or cardiac death.Results Cys-C in patients with heart failure was significantly higher（ P〈0. 05）. There was positive correlation between Cys-C and BNP（ rs= 0. 734,P〈0. 05）. Both highheart failure recurrence and high cardiac death were seen in higher Cys-C patients（ P〈0. 05）. Conclusion There was positive correlation between serum Cys-C and degree of heart failure. Patients with higher Cys-C had early renal damage,heart failure recurrence or cardiac death. Both of recent heart failure recurrence rate and cardiac mortality were higher in patients with higher CysC.. Cys-C might bea valubleindex to asses short-term prognosis of heart failure.

关 键 词：胱抑素 C: 慢性心力衰竭: 近期预后 

分 类 号：R541.61[医药卫生—心血管疾病]