红细胞分布宽度在慢性阻塞性肺疾病中的诊断价值  

Diagnostic value of red blood cell distribution width on chronic obstructive pulmonary disease

作　　者：胡琼英[1] 张爽[1] 曾瑜[1] 张朝明[1] 

机构地区：[1]成都中医药大学附属医院检验科,四川成都610072

出　　处：《中国医药导报》2016年第10期123-126,共4页China Medical Herald

摘　　要：目的探讨红细胞分布宽度（RDW）对慢性阻塞性肺疾病（COPD）的诊断价值,为COPD的早期诊断发掘新的标志物。方法采集2015年11~12月成都中医药大学附属医院COPD患者（204例）、肺恶性肿瘤患者（96例）及健康体检者（71例）的静脉血2 m L,检测三组的RDW值,one-way ANOVA法比较三组间RDW值变化。绘制RDW诊断COPD的受试者工作曲线（ROC曲线）,计算灵敏度、特异度和约登指数,诊断界值cut-off值。结果与健康体检者比较,RDW在COPD患者及肺恶性肿瘤患者中均显著升高（P〈0.05）;ROC曲线下面积（AUC）为0.875,最大约登指数为0.624,灵敏度和特异度分别为69.3%和93.1%,对应的cut-off值为45.55。结论 RDW对COPD具有较高的诊断价值,可作为COPD诊断和鉴别诊断的新指标。Objective To discuss the diagnostic value of red blood cell distribution width（RDW） on chronic obstructive pulmonary disease（COPD）, and explore a new diagnostic marker for COPD. Methods From November to December2015, in Teaching Hospital of Chengdu University of Traditional Chinese Medicine, venous blood 2 m L of COPD patients（204 cases）, pulmonary malignant tumor patients（96 cases） and health people（71 cases） were collected, the RDW levels were detected and compared by one-way ANOVA. The receiver operator characteristic curve（ROC） was drew, sensitivity, specificity and Youden＇s index（YI）, cut-off value were calculated. Results RDW levels rose significantly in COPD patients and pulmonary malignant tumor patients compared with health group（P 〈0.05）. YI was 0.624 while the cut-off was 45.55, and the sensitivity and specificity were 69.3% and 93.1%, respectively. Conclusion RDW may be potential a biomarker in the diagnosing of COPD.

关 键 词：红细胞分布宽度 慢性阻塞性肺疾病 诊断标志物 诊断价值 

分 类 号：R563.9[医药卫生—呼吸系统]