纤毛长度信号通路调节机制的研究进展  

Progress of intracellular signaling pathways regulating ciliary length

作　　者：王晶[1] 王雪松[2] 薛金梅[3] 

机构地区：[1]山西医科大学,山西太原030001 [2]滨州市中心医院耳鼻咽喉科,山东滨州251700 [3]山西医科大学第二医院耳鼻咽喉头颈外科,山西太原030001

出　　处：《山东大学耳鼻喉眼学报》2016年第2期98-101,共4页Journal of Otolaryngology and Ophthalmology of Shandong University

基　　金：山西省自然基金(20130110552);山西省卫生厅青年项目资助(201201080)

摘　　要：纤毛广泛分布于机体多种类型细胞表面,在体内发挥着重要的生理作用,其长度异常必定导致纤毛功能的异常,进而导致纤毛相关疾病;纤毛长度受到多种因素如纤毛内转运机制、细胞周期、相关基因及信号通路的影响,其中信号通路包括NF-κB、Wnt、Shh、Notch、第二信使等,了解纤毛长度信号调节机制对相关疾病的诊疗具有指导意义。Cilia are located on almost all cell types of the human body,and perform key tasks for a variety of organs,but defects in the length or function of them are involved in the pathogenesis of several cilia-related disorder. Ciliary length can be regulated by the process of intraflagellar transport（ IFT）,signal transduction pathw ays,cell cycle,etc. All of these stages are tightly regulated to produce a cilium of the right size at the right time. Signaling regulation involves c AMP,NF-κB,Wnt,Shh and Notch. To further explore intracellular molecules that regulate ciliary length is of great importance for the diagnosis and treatment of certain cilia-related disorder.

关 键 词：纤毛 纤毛长度 信号通路 

分 类 号：Q471[生物学—生理学]