超重或单纯性肥胖儿童人体质量指数与心血管疾病风险因子的相关性研究  

Study on the correlation between body mass index and cardiovascular disease risk factors of overweight or simple obesity children

作　　者：林元涛 杨光[2] 王红宇[1] 张燕[1] 殷明刚 袁峰[4] 

机构地区：[1]自贡市第一人民医院儿科,四川643000 [2]中国人民解放军总医院儿科,北京100853 [3]自贡市第一人民医院检验科,四川643000 [4]自贡市第一人民医院核医学科,四川643000

出　　处：《中华妇幼临床医学杂志（电子版）》2016年第2期148-153,共6页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

基　　金：北京市自然科学基金面上项目(7142150);海南省社会发展科技专项基金项目(2015SF05)~~

摘　　要：目的探讨超重或单纯性肥胖儿童人体质量指数(BMI)与心血管疾病风险因子的相关性。方法选择2013年3月至2015年1月,在自贡市第一人民医院儿科初次就诊即诊断为超重或单纯性肥胖的62例儿童纳入观察组,以及同期进行健康体检的46例正常体重儿童纳入对照组。统计学比较两组儿童一般临床指标[年龄、人体质量指数(BMI)、腰围、收缩压、舒张压],脂代谢指标[动脉粥样硬化指数(AI)、总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、三酰甘油(TG)],以及糖代谢指标[胰岛素抵抗指数(HOMA-IR)、口服葡萄糖耐量试验2小时血糖(OGTT GLU2h)、空腹血糖、空腹胰岛素]差异;并对观察组儿童BMI与上述9项心血管疾病风险因子(脂代谢和糖代谢指标)进行相关性分析。两组儿童年龄及性别构成比比较,差异无统计学意义(P>0.05)。所有参与本次研究的儿童,均由其监护人签署知情同意书,并获得自贡市第一人民医院伦理委员会同意。结果 1观察组儿童一般临床指标BMI[(31.8±2.3)kg/m2]、腰围[(86.7±12.3)cm]及收缩压[(128.0±11.2)mmHg(1mmHg=0.133kPa)]均较对照组[(19.4±0.8)kg/m2、(61.1±8.0)cm、(102.0±12.9)mmHg]高,且差异有统计学意义(t=-38.171、-12.770、-2.120,P<0.05)。2观察组儿童脂代谢指标AI(4.0±0.8)及TC、LDL、TG浓度[(4.9±0.6)mmol/L、(3.07±0.23)mmol/L、(1.85±0.13)mmol/L]均较对照组高[(1.0±0.4)、(4.0±0.4)mmol/L、(1.46±0.13)mmol/L、(0.80±0.21)mmol/L],而HDL浓度[(0.89±0.09)mmol/L]则较对照组[(2.14±0.49)mmol/L]低,且差异均有统计学意义(t=-35.96、-7.66、-51.29、-22.03、36.62,P<0.01)。3观察组儿童糖代谢指标HOMA-IR(12.5±1.3)及OGTT GLU2h、空腹血糖、空腹胰岛素浓度[(7.5±0.9)mmol/L、(5.97±0.22)mmol/L、(47.0±4.2)pmol/L]均较对照组高[(2.8±0.3)、(4.0±0.4)mmol/L、(4.47±0.13)mmol/L、(14.0±1.4)pmol/L],且差异均有统计学意义(t=-38.64、-25.44、-43.65、-57.31,P<0.01)。4观察组�Objective To explore the correlation between body mass index （BMI） and cardiovascular disease risk factors of overweight or simple obesity children. Methods From March 2013 to January 2015, a total of 62 initial visit children who were diagnosed as overweight or simple obesity in department of Pediatrics, Zigong First People＇s Hospital, were included into observation group, and another 46 children with normal weight who received health examination at the same time were included into control group. The differences between two groups in the aspects of general clinical index [age, body mass index （BMI）, waist circumference, systolic blood pressure, diastolic blood pressure-], lipid metabolism index [atherosclerosis index （AI）, total cholesterol （TC）, high-density lipoprotein （t-IDL）, low density lipoprotein （LDL）, triglyceride （TG）-], and sugar metabolism index [indexes of insulin resistance （HOMA-IR）, glucose concentration after 2 hours of oral glucose tolerance test （OGTT GLU2h）, fasting blood glucose, fasting insulin-] were statistically compared. Meanwhile,the correlation between BMI and 9 risk factors for cardiovascular disease（lipid metabolism and sugar metabolism index above mentioned） in observatidn group were analyzed. There were no significant differences between two groups in age and gender constituent ratio（P〉 0.05）. The guardian of all children participated in this study signed the informed consent, a±ad the procedure of this study was approved by the Ethical Review Board of Investigation in Human±Being of Zigong First People＇s Hospital. Results O The general clinical index of children in observation group including BMI [（31.8±2.3） kg/mZ],waist circumference[（86.7±12.3） cm] and systolic blood pressure[（128.0± 11.2） mmHg （1 mmHg=0. 133 kPa-] were higher than those of control group[（19.4±0.8） kg/m2 , （61.1 ± 8. 0） cm, （102. 0 ±12. 9） mmHg], and the differences were statistically significant （t = -38. 171 ,-12. 770,- 2. 1

关 键 词：小儿肥胖症 超重 人体质量指数 心血管疾病 危险因素 儿童 

分 类 号：R723.14[医药卫生—儿科]