补肾解毒健脾冲剂对高危结局慢性乙肝病毒携带者血清免疫因子的作用  

Effects of Bushen Jiedu Jianpi Electuary on Serum Cytokines in High Risk Ending Chronic HBV Carriers

作　　者：程晶[1] 李群[1] 唐海鸿[1] 邢宇锋[1] 陈亮[1] 张来[1] 占伯林[1] 贺劲松[1] 周大桥[1] 

机构地区：[1]广州中医药大学深圳附属医院肝病科,广东深圳518033

出　　处：《湖北中医药大学学报》2016年第2期18-21,共4页Journal of Hubei University of Chinese Medicine

基　　金：广东省中医药局科研课题(项目编号:20131028)

摘　　要：目的分析补肾解毒健脾冲剂对高危结局慢性乙肝病毒(HBV)携带者血清免疫因子的作用。方法将200例高危慢性乙肝病毒携带患者,随机分为两组。治疗组施予补肾解毒健脾冲剂治疗,对照组施予安慰剂干预,72周后观察治疗前以及治疗后血清乙肝病毒的脱氧核糖核酸(DNA)定量和辅助性T细胞1(Th1)/辅助性T细胞2(Th2)型细胞因子水平变化。结果治疗组血清HBV DNA下降>1log10、>2log10及>3log10的患者比例明显高于对照组(P<0.01)。治疗组Th1细胞因子白介素12和干扰素γ水平显著升高(P<0.01),Th2因子白介素4和白介素10水平明显下降(P<0.01),治疗前后差值与对照组比较差异有统计学意义(P<0.01)。结论补肾解毒健脾冲剂可以通过恢复特异性T细胞免疫功能来抑制高危结局慢性乙肝病毒携带者HBV的复制。Objective To investigate the effects of Bushen Jiedu Jianpi electuary on serum cytokines with high risk ending chronic HBV carriers. Methods 200 chronic HBV carriers were randomly divided into treatment group and control group. Treatment group received Bushen Jiedu Jianpi electuary,control group received placebo. The course of treatment was 72 weeks. Serum HBV DNA level and helper T cell（ Th1 /Th2） cytokines levels in both groups were detected before and after treatment. Result After 72 weeks of treatment,the proportions of serum HBV DNA levels in treatment group decreased by more than 1log10,2log10,and 3log10,significantly higher than those in control group（ P〈0. 01）. The levels of IL- 12 and IFN γ increased significantly and those of IL- 4 and IL- 10 decreased significantly in treatment group（ P〈0. 01）. Compared with the control group,the variation of the cytokine levels before and after treatment in treatment group were significantly different（ P〈0. 01）. Conclusion Bushen Jiedu Jianpi Electuary is effective in inhibiting HBV replication probably by restoring immune function of specific T cells in chronic HBV carriers.

关 键 词：高危结局慢性乙肝病毒携带者 中医药疗法 补肾解毒健脾冲剂 免疫因子 

分 类 号：R286[医药卫生—中药学]