一种基于1,3,4-噁二唑衍生物的荧光探针对锌离子和焦磷酸根的接力识别  

A 1,3,4-oxadiazole derivative-based fluorescent probe for relay recognition of Zn^(2+) and pyrophosphate

作　　者：汤立军[1] 郑竹轩 边延江[1] 

机构地区：[1]渤海大学化学化工学院化学系,辽宁锦州121013

出　　处：《化学研究与应用》2016年第5期617-622,共6页Chemical Research and Application

基　　金：国家自然科学基金项目(21176029;21476029)资助;辽宁省高等学校优秀科技人才支持计划(LR2015001)资助

摘　　要：设计合成了一种基于1,3,4-噁二唑衍生物的接力识别功能荧光探针L,在水溶液中(HEPES 0.01 mol·dm^(-3),pH=7.4)探针L对Zn^(2+)具有良好的选择性,可引起荧光增强并红移,二者的结合比为1:2。原位生成的配合物L-2Zn^(2+)可接力识别焦磷酸根(PPi),PPi与配合物中的锌离子继续络合,并可引起发射蓝移。通过L与Zn^(2+)和PPi的相继作用,扰动了L的激发态分子内质子转移性质,实现了荧光信号比率输出的接力识别。A 1,3,4-oxadiazole derivative-based fluorescent probe L was designed and synthesized. In HEPES buffered(0. 01 mol· dm-3,pH=7. 4)water solution,L exhibited high selectivity towards Zn2+ with a red-shifted emission. L binds Zn2+ through a 1:2 binding stoishiometry. The in situ formed L-2Zn2+complex could act as a relay recognition probe to pyrophosphate(PPi),PPi could further bind the zincionsin the complex and results in emission blue shift. Through successive interaction of L with Zn2+and PPi,the excited state intermolecular proton transfer( ESIPT) property was perturbed,thus a ratiometric emission output relay recognition was achieved.

关 键 词：荧光探针 接力识别 锌离子 焦磷酸根 

分 类 号：O657.3[理学—分析化学]