树状寡聚乙二醇修饰的苯丙氨酸衍生物的合成与溶液性质研究  

Synthesis and solution properties of phenylalaninate derivatives with branching oligoethyleneoxy chains

作　　者：吴鹏超[1] 余攀[1] 王硕[1] 王丹[1] 李良春[1] 

机构地区：[1]西南科技大学生命科学与工程学院,四川绵阳621010

出　　处：《化学研究与应用》2016年第5期711-715,共5页Chemical Research and Application

基　　金：国家自然科学基金项目(21002099)资助

摘　　要：以苯丙氨酸甲酯与含寡聚乙二醇链的间苯二胺缩合,合成了新型含寡聚乙二醇链的氨基酸分子10和11,其结构经~1H NMR,^(13)C NMR,ESI-HRMS表征。利用UV光谱对化合物4、8、11的溶液性质进行了研究,结果表明,化合物11具有低临界溶液温度性质。A novel thermosensitive amino acid derivative with oligoethyleneoxy chains,was designed and synthesized from L-methyl phenylalaninate and 3,5-diaminobenzoic acid derivative with oligoethyleneoxy chains. The structures were characterized by 1H NMR,13 C NMR,IR and ESI-HR-MS. The solution properties of 4,8,10,11 were investigated by UV-vis. The results showed that 11 exhibited thermosensitivity and LCST properties.

关 键 词：苯丙氨酸甲酯 寡聚乙二醇 低临界溶液温度 UV光谱 

分 类 号：O621.2[理学—有机化学]