口腔颌面部上皮样血管瘤6例临床病理分析及文献复习  

Clinical and Pathological Analysis of Six Epithelioid Hemangioma in Oral and Maxillofacial Region and Review of the Literature

作　　者：郑晓丹[1] 金旭斌[1] 郑丽端[2] 程波[1] 戴琳[3] 

机构地区：[1]华中科技大学附属协和医院口腔科,湖北武汉430022 [2]华中科技大学附属协和医院病理科 [3]武汉市第一医院口腔科,湖北武汉430022

出　　处：《口腔医学研究》2016年第4期370-373,共4页Journal of Oral Science Research

基　　金：国家自然科学基金面上项目(编号:81370405);武汉市卫计委临床医学科研项目(编号:WX13A04)

摘　　要：目的:探讨口腔颌面部上皮样血管瘤的临床病理学特征、诊断、预后及临床意义。方法:收集6例口腔颌面部上皮样血管瘤病史、临床资料;大体检查、HE染色后光学显微镜下观察,全部标本行免疫组织化学染色分析其免疫结构,并复习相关文献。结果:6例患者中,男女各3例。肿瘤分别位于耳周(4例)及腭部(2例);都表现为表浅单发性肿块,1例有创伤史。组织学表现为增生的毛细血管和小血管,血管内皮细胞呈上皮样或组织细胞样改变;病变内见以嗜酸性粒细胞为主的慢性炎症细胞浸润。免疫组织化学检测,所有病例血管内皮细胞Vimentin、CD31、CD34阳性,SMA显示血管周围完整的肌外周细胞层,S-100、PanCK染色血管内皮细胞阴性。手术治疗后1例复发,均无转移。结论:上皮样血管瘤是一种良性血管病变,可能与局部创伤有关。手术局部完全切除是其主要治疗方式,若切除不彻底容易复发。准确的术前和术中诊断对手术完整切除有重要的意义。Objective：To investigate the clinicopathological features,diagnosis,prognosis,and clinical significance of epithelioid hemangiomas in the oral and maxillofacial region.Methods：The case history and clinicopathological features of six patients with epithelioid hemangioma in the oral and maxillofacial region were reviewed.All sections were observed microscopically by gross examination and HE staining.The immune structure was analyzed by immunohistochemistry staining and related literatures were reviewed.Results：Six patients were three males and three females,and the average age was 26-year old.The tumors were located around the ear（n=4）and palatine（n=2）.All sections were manifested as superficial single mass and one patient with history of trauma.Histopathologically,the lesions were characterized by proliferation of capillaries and small blood vessels,and vascular endothelial cells were present as epithelioid cells or histiocytes.Chronic inflammatory cells could be observed in the whole lesion and most of them could be eosinophilics.For immunohistochemistry,vascular endothelial cells were positive for Vimentin,CD31 and CD34,SMA shows perivascular positive,S-100,Pan CK staining were negative in all the cases.Only one case recurred after surgery and there was no metastasis in all of the cases.Conclusion：Epithelioid hemangioma is a benign vascular lesion,and may be related to local trauma.The effective treatment is the locally complete excision and it is particularly liable to relapse if not completely removed.Accurate preoperative and intraoperative diagnosis is very important for complete surgical resection.

关 键 词：上皮样血管瘤 口腔颌面部 临床病理特征 

分 类 号：R739.8[医药卫生—肿瘤]