亚硒酸钠小鼠骨髓嗜多染红细胞微核试验研究  

Study on Micronucleus Test of Polychromatics Erythrccytes in Bone Marrow of Sodium Selenium

作　　者：李元新[1] 刘来利[1] 王必成[1] 张鹏岳[1] 

机构地区：[1]甘肃省畜牧兽医研究所,甘肃平凉744000

出　　处：《畜牧兽医杂志》2016年第3期20-21,共2页Journal of Animal Science and Veterinary Medicine

基　　金：甘肃省科技计划资助项目;项目编号:0805TCYL006

摘　　要：为评价亚硒酸钠的致突变性,进行了小鼠骨髓嗜多染红细胞(PCE)微杭试验。结果表明:当受试物终浓度为2mg/kg,1mg/kg剂量组PCE微核率与阴性对照组比较有极显著性差异(p<0.01),结果为阳性;0.5mg/kg剂量组PCE微核率与阴性对照组比较,差异均无统计学意义(p>0.05),为阴性结果。结论:亚硒酸钠具有一定的致突变性。The mutagenicity of sodium selenite was evaluated by the micronucleus test of polychromatics erythrccytes in bone marrow. The results showed that at the concentration of 2 mg/kg, 1 μg/mL dosage, the rate of micronucleus of polychromatics erythrecytes in bone marrow in treatment group was very significant different than control group （P〈0.01）, which was positive. PCE micronueleus rate at 0.5 mg/kg was not significant （P〉0.05） compares with control group, which was nega tive. In conclusion, Sodium selenite has mutagenicity to some extent.

关 键 词：亚硒酸钠 PCE 微核 

分 类 号：S852.651[农业科学—基础兽医学]