309例pSS患者生活质量及焦虑抑郁情况调查研究  

Evaluation of Life Quality,Anxiety and Depression on 309 Patients with Primary Sjgren's Syndrome

作　　者：刘兆祥[1] 郝伟欣[1] 

机构地区：[1]中国医学科学院/北京协和医学院北京协和医院中医科,100730

出　　处：《医学研究杂志》2016年第4期101-104,共4页Journal of Medical Research

摘　　要：目的研究原发性干燥综合征(primary Sjgren's syndrome,p SS)患者生活质量及焦虑抑郁情况并分析其影响因素。方法筛选309例p SS患者(男性5例,女性304例)作为研究对象,应用健康状况调查问卷(SF-36)评估患者生活质量,医院焦虑抑郁量表(HADS)评估患者焦虑抑郁情况。结果 p SS患者的SF-36各维度积分明显低于普通人群,HADS量表焦虑评分(HAS)、抑郁评分(HDS)均高于内科就诊人群(女性患者)(P<0.05)。进一步对女性p SS患者分析显示,疼痛评分、疲劳乏力评分与SF-36生理健康领域得分下降有关;疲劳乏力评分与心理健康领域得分下降有关。疼痛评分、疲劳乏力评分与HAS和HDS评分升高均有关。年龄的增长与HAS评分下降有关,皮肤干燥评分与HDS评分升高有关。结论 p SS患者的生活质量较普通人群明显下降,且具有明显的焦虑抑郁情绪。疼痛、疲劳乏力是影响生活质量和焦虑抑郁情绪的主要因素。Objective To investigate the life quality, degree of anxiety and depression in patients with primary Sj？gren＇s Syndrome （pSS） and analyze the influential factors. Methods A total of 309 patients with pSS （5 men, 304 women） were recruited. A health condition questionnaire （SF-36） was used to assess patients＇ life quality, and a hospital anxiety and depression scale （HADS） was adopted to assess the degree of anxiety and depression. Patients＇ medical data, including symptoms grading scores, system involvement and complications, was recorded for further statistical analysis. Results Patients with pSS scored obviously lower than the general population in SF-36. Besides, they obtained high scores in HAS （Hospital Anxiety Scale） and HDS （Hospital Depression Scale） （P〈0.05）.For female patients, serious pain and fatigue were negatively related to the physical condition score （PCS） of life quality; feeling of fatigue was negatively related to the mental condition score （MCS） of life quality. Young patients were prone to get higher HAS score, while patients with xeroderma tended to get higher HDS score. Feelings of pain and fatigue could lead to both higher HAS and HDS score. Conclusion Patients with pSS have lower quality of life than the general population, and show obvious anxiety and depression. Pain and fatigue are predictors of lower life quality and more obvious anxiety and depression.

关 键 词：原发性干燥综合征 生活质量 焦虑抑郁 SF-36 HADS 

分 类 号：R593[医药卫生—内科学]