吸烟对慢性阻塞性肺疾病及慢性阻塞性肺疾病-哮喘重叠综合征患者呼出气一氧化氮的影响  

Effects of smoking on exhaled nitric oxide in patients with COPD or asthma overlap COPD syndrome

作　　者：刘鹏飞[1] 赵大辉[1] 张杜超[1] 肖坤[1] 闫鹏[1] 解立新[1] 

机构地区：[1]解放军总医院呼吸科,北京100853

出　　处：《解放军医学院学报》2016年第4期317-319,323,共3页Academic Journal of Chinese PLA Medical School

基　　金：海南省自然科学基金项目(814330);中央保健课题(W2013BJ11)~~

摘　　要：目的探索吸烟对慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)、慢性阻塞性肺疾病-哮喘重叠综合征(asthma COPD overlap syndrome,ACOS)患者呼出气一氧化氮的影响。方法回顾性分析2014年6-12月在我院确诊的105例COPD患者和79例ACOS患者的临床资料、呼出气一氧化氮水平(fractional exhaled nitric oxide,FeNO)和肺功能的检测结果,并选取172例健康人作为对照。结果吸烟COPD患者FeNO平均值为(25.07±9.78)ppb,明显低于不吸烟COPD患者的FeNO平均值(29.46±8.12)ppb(P<0.05)。吸烟ACOS患者FeNO平均值为(34.53±18.11)ppb,明显低于不吸烟ACOS患者的FeNO平均值(42.50±15.53)ppb(P<0.05)。健康对照组中吸烟者FeNO平均值为(16.57±4.19)ppb,不吸烟者为(17.01±4.17)ppb,差异无统计学意义。ACOS组吸烟患者中,吸烟指数与FeNO呈负相关(r=-0.42,P=0.015);COPD组吸烟者中,这种相关性不明显。结论吸烟可以降低COPD、ACOS患者的呼出气一氧化氮含量,在ACOS组吸烟患者中,吸烟指数越高,患者的呼出气一氧化氮水平越低。Objective To investigate effects of smoking on exhaled nitric oxide in patients with chronic obstructive pulmonary diseases（COPD） or asthma COPD overlap syndrome（ACOS）. Methods A total of 105 patients with COPD, 79 patients with ACOS and 172 healthy people were enrolled in this study. Clinical data, exhaled nitric oxide（FeNO） measurements and pulmonary function test results were retrospectively analyzed. Results The level of FeNO in non-smoking patients with COPD was significantly higher than smokers with COPD [（29.46±8.12） ppb vs（25.07±9.78） ppb, P 〈0.05], and the level of FeNO in non-smoking patients with ACOS was significantly higher than smokers with ACOS [（42.50±15.53） ppb vs（34.53±18.11） ppb, P 〈0.05], while the FeNO level in healthy smokers was（16.57±4.19） ppb and（17.01±4.17） ppb in non-smoking residents with no statistically significant difference. The FeNO values in smoking patients with ACOS were negatively related to the smoking index（r=-0.42, P=0.015）.Conclusion Smoking can decrease FeNO value in patients with COPD or AOCS. In patients with ACOS group, the higher the smoking index is, the lower the FeNO value becomes.

关 键 词：呼出气一氧化氮 慢性阻塞性肺疾病 慢性阻塞性肺疾病-哮喘重叠综合征 

分 类 号：R563.9[医药卫生—呼吸系统]