基于无监督数据挖掘中药内服治疗颈性眩晕的组方用药规律分析  

Unsupervised data mining for prescription and medication regularity for treatment of cervical vertigo

作　　者：丁心香 王爱国[2] 郑昆仑[2] 信金党[2] 胡馨宇[1] 谷福顺[2] 

机构地区：[1]天津中医药大学,天津300193 [2]天津中医药大学第二附属医院,天津300150

出　　处：《中国中药杂志》2016年第5期955-959,共5页China Journal of Chinese Materia Medica

基　　金：天津市中医重点专科项目;天津市中医药管理局中医;中西医结合科研课题(13106);天津市高等学校科技发展基金项目(20120217)

摘　　要：文章通过检索中国知网近5年来中医治疗颈性眩晕的内服方剂,采用关联规则算法、复杂系统熵聚类等无监督数据挖掘方法,分析处方中各种药物的使用频次、药物之间的关联规则、核心药物组合和新处方。利用中医传承辅助平台系统软件(TCMISS)对筛选出的101个方剂中的154味中药进行分析,确定治疗颈性眩晕的药物使用频次,分析核心用药特点、配伍规律以及高频用药剂量,挖掘出了14个核心药物组合和7个新方组合。其组方用药规律阐明了治疗颈性眩晕以平肝潜阳药、活血化瘀药、利水渗湿药、补气活血药、滋补肝肾药为主,治则为滋补肝肾、活血化瘀通窍、化痰祛湿、平肝潜阳通络、益气活血养血。旨在总结中药内服治疗椎动脉型颈椎病的高频单味中药、高频药物组合和疗效显著的高频用药剂量,探讨目前治疗颈性眩晕组方用药规律,指导临床用药。Vertebral artery type cervical spondylosis is a common type of cervical spondylosis,also known as cervical vertigo. In recent years,with the increase of people＇s life pace and the number of office staff,the incidence rate has been rising year by year,with a trend of younger age. Because traditional Chinese medicine has unique advantages in treating cervical vertigo,it is necessary to study the regularity of the Chinese medicine for cervical vertigo. But at present,the research is mainly based on the statistics for frequency and proportion of herbs. In addition,in the process of diagnosis and treatment of Chinese medicine,personal experience also caused differences in prescription compatibility and drug dosage,which makes difficult guarantee for the safety and effectiveness of drug treatment. So,this paper is based on literatures about the traditional Chinese medicine in treatment of cervical vertigo in the past 5 years,by using association rules algorithm,complex system entropy clustering and other non supervised data mining methods. Analysis was made for the use of various drugs in the frequency,the association rules,the core drug combination and the new prescriptions. The traditional Chinese medicine inheritance support system（ TCMISS） was utilized to analyze 154 drugs from the 101 prescriptions,determine the use frequency of drugs,analyze the characteristics and the compatibility of core drugs,and dig out 14 core drug combinations and7 new prescription combinations. The prescription and medication regularities illustrates the drugs for treatment of cervical vertigo,including those for flating liver and suppressing yang,invigorating the circulation of blood to remove blood stasis,reducing water and permeating dampness,increasing qi and activating blood,and nourishing the liver and kidney mainly. Treatment rules are nourishing liver and kidney,invigorating the circulation of blood stasis Tongqiao,reducing phlegm and dampness,flating liver and suppressing yan,dredging collaterals,supplementing qi and nouris

关 键 词：颈性眩晕 中药 用药规律 

分 类 号：R274.9[医药卫生—中西医结合]