亚急性甲状腺炎患者采用不同剂量泼尼松治疗的效果对比分析  

COMPARATIVE ANALYSIS OF CLINICAL EFFECT ON SUBACUTE THYROIDITIS BY DIFFERENT DOSES OF PREDNISONE TREATMENT

作　　者：周琼[1] 余书勇[2] 陈森良[1] 

机构地区：[1]解放军第一八七医院核医学科,海南省海口市571159 [2]解放军第一八七医院肿瘤外科学,海南省海口市571159

出　　处：《中国煤炭工业医学杂志》2016年第4期522-525,共4页Chinese Journal of Coal Industry Medicine

基　　金：海南省自然科学基金项目(编号:808249)

摘　　要：目的分析亚急性甲状腺炎患者应用不同剂量泼尼松药物治疗的路径及疗效。方法选取该院2013年8月—2014年12月收治的84例亚急性甲状腺炎患者作为临床研究对象,采用随机数字分组法将84例患者随机均分为观察组与对照组,观察组42例患者给予小剂量泼尼松药物治疗方案,对照组42例患者给予常规大剂量泼尼松药物治疗方案,综合对比二组患者临床症状、体征改善时间、预期疗效及药物不良反应发生率差异。结果经不同剂量泼尼松药物方案治疗后,观察组42例患者各项临床症状、体征缓解时间及临床治疗总有效率,相比对照组42例患者,差异无统计学意义(P>0.05)。但对比二组患者药物不良反应情况可知,观察组42例患者药物不良反应发生率为11.92%,对照组42例患者药物不良反应发生率为38.08%,观察组显著低于对照组,差异有统计学意义(P<0.05)结论亚急性甲状腺炎患者临床治疗过程中,科学给予小剂量泼尼松药物治疗方案,相比常规大剂量药物治疗方案而言,可有效降低患者药物不良反应,强化患者预后生活质量,值得临床综合应用推广。Objective To analyze the medication path and curative effect of patients with subacute thyroiditis by using doses of prednisone.Methods From August 2013 to December 2014 admitted during the period of 84 patients with subacute thyroiditis were selected as clinical research subjects,using random digital grouping,84 patients were randomly divided into observation group and control group.The observation group of 42 cases patients were given small dose of prednisone drug treatment,while the control group patients were given regular high-dose prednisone drug treatment,then clinical symptoms and signs improved time,expected curative effect and adverse reaction rate differences were compared between the two groups of patients.Results After different doses of prednisone medication,the clinical symptoms,physical signs and clinical treatment of total effective rate were no significant difference between the observation group and the control group,P〈0.05,but adverse reaction of the observation group of patients was 11.92%,significantly lower than that of the control group（38.08%）,and the difference was statistically significant,P〈0.05.Conclusions Compared to conventional high-dose drug treatment for the patients with subacute thyroiditis,small doses of prednisone can effectively reduce the incidence of adverse reactions,strengthening the quality of life,and it is worthy of clinical promotion.

关 键 词：亚急性甲状腺炎 泼尼松 药物剂量 

分 类 号：R582[医药卫生—内分泌]