FRAX评估北京地区中老年人群骨折风险的回顾性研究  

The retrospective study of FRAX in predicting the fracture risk of senile people in Beijing

作　　者：常帅[1] 张智海[1] 刘忠厚 董威[3] 李宝[3] 

机构地区：[1]中国医科大学航空总医院脊柱外科,北京100012 [2]中国老年学学会骨质疏松委员会(OCCGS),北京100102 [3]中国医科大学航空总医院影像中心,北京100012

出　　处：《中国骨质疏松杂志》2016年第4期447-451,474,共6页Chinese Journal of Osteoporosis

摘　　要：目的评价WHO发布的骨折风险评估工具FRAX对北京地区中老年人群的适用性,预测北京地区不同性别及年龄亚组中老年人群的骨折风险,讨论既往骨折病史对于FRAX的影响。方法对3021例北京地区中老年人群进行分组性研究。输入相关资料及FRAX工具中所包含的危险因素,计算未来10年内发生全身骨质疏松性骨折及髋部骨折的风险概率,比较既往骨折病史人群对FRAX预测结果影响。结果北京地区女性中老年人群未来10年内骨折风险远高于同年龄组男性;伴随年龄增大,未来10年内发生全身骨质疏松性骨折及髋部骨折的风险概率不分性别均同步增高。有既往骨折病史的老年人群10年内再发骨折风险远高于无骨折史人群。结论利用FRAX工具可以对北京地区中老年人群骨折风险做出有效评估,针对于不同性别、不同年龄亚组的人群,联合髋部BMD值后获取的FRAX预测在既往骨折或未骨折患者中均具有临床应用价值。FRAX评估工具在骨质疏松的诊断、治疗及预后评价等方面具有良好的临床应用价值。Objective To evaluate the applicability of FRAX,the fracture risk assessment tool published by WHO,in senile population in Beijing,to predict the fracture risk of senile population in different gender groups in Beijing,and to discuss the effect of the history of previous fracture on FRAX. Methods A total of 3021 senile people were grouped and studied. The FRAX toolrelated risk factors were input. The 10-year fracture probability of the hip and osteoporotic fractures was calculated. The results of FRAX in population with or without fracture history were compared. Results The fracture risk of the female population in the next10 years was much higher than that of the male population with the same age. Along with the increase of age,the probability of fracture risk of the hip and the whole body increased simultaneously. The fracture risk of the recurrence in next 10 years in population with previous fractures was much higher than that in people without fracture history. Conclusion The FRAX tool can be effectively applied to assess the fracture risk of senile population in Beijing. For the people of different gender and different age subgroups,FRAX tool combined with the hip BMD has clinical value in patients with or without previous fractures. FRAX evaluation software has a good clinical value in the diagnosis,treatment,and prognosis of osteoporosis.

关 键 词：骨质疏松 FRAX 骨折风险 

分 类 号：R683[医药卫生—骨科学]