南京地区慢性阻塞性肺疾病患者的阻塞性睡眠呼吸暂停低通气综合征流行状况  

Prevalence of obstructive sleep apnea-hypopnea syndrome in patients with chronic obstructive pulmonary disease in Nanjing

作　　者：王文晶[1] 谷伟[1] 张希龙[2] 

机构地区：[1]南京医科大学附属南京医院呼吸科,210006 [2]南京医科大学第一附属医院呼吸科,210029

出　　处：《中华肺部疾病杂志（电子版）》2016年第2期171-174,共4页Chinese Journal of Lung Diseases(Electronic Edition)

摘　　要：目的探讨南京地区慢性阻塞性肺疾病(COPD)患者阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的发状况及其相关特征。方法对受试人群进行病情评估,内容包括:BMI、6 min步行试验测试、慢性阻塞性肺病评估测试(CAT)、Epworth嗜睡量表(ESS)测试、肺功能检测、多导睡眠监测(PSG)。结果共计纳入患者40例,其中患有重叠综合征(OS)的患者为21例(52.5%),仅患COPD而不存在OSAHS的为19例(47.5%)。两组间BMI、颈围有显著性差异。肺功能和6 min步行试验两组间均无显著性差异。多导睡眠监测结果提示两组间存在显著性差异,OS组呼吸暂停低通气指数(AHI)明显较高,为22.2±19.3次/h,而COPD非OSAHS组基本正常。CAT评分和ESS测试显示两组间有显著性差异。结论 C级至D级COPD患者具有较高的OSAHS发病率,OS患者较单纯COPD患者生活质量和睡眠质量更差。Objective The purpose of this study was to investigate prevalence of obstructive sleep apnea-hypopnea syndrome（ OSAHS） in patients with moderate to severe chronic obstructive pulmonary disease（ COPD） to test the hypothesis that COPD is associated with an increased prevalence of OSAHS. Methods Patients with moderate to severe COPD of Nanjing were enrolled prospectively. Exercise tolerance,questionnaires related to symptoms,sleep,and quality of life,and polysomnography were obtained. Results Forty patients had full polysomnography suitable for analysis. OSAHS was present in 21 subjects（ 52.5 %）. The differences of BMI, neck circumference between overlap syndrome（ OS） group and COPD group were significant. Assessments of lung function and exercise tolerance between two groups were the same. Results of PSG showed significantly higher apnea hypopnea index（ AHI）（ 22.2±19.3 events/h） of OS group than that of COPD group,which was almost normal. We found a marked difference of CAT and ESS results between the two groups. Conclusion Obstructive sleep apnea is highly prevalent in moderate to severe COPD patients. Quality of life and sleep is also poor among this selected group.

关 键 词：肺疾病 慢性阻塞性 低通气综合征 睡眠呼吸暂停 阻塞性 重叠综合征 呼吸暂停低通气指数 

分 类 号：R563[医药卫生—呼吸系统]