高敏C反应蛋白对冠心病介入治疗病人预后的临床价值  

Clinical Prognosis of High-sensitivity C-Reactive Protein Guiding Interventional Therapy for Coronary Heart Disease

作　　者：范军[1] 张虹[1] 赵菁[1] 赵兴山[1] 郝志华[2] 

机构地区：[1]北京积水潭医院,北京100035 [2]河北省人民医院

出　　处：《中西医结合心脑血管病杂志》2016年第4期395-398,共4页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：河北省2014年度医学科学研究重点课题(No.ZD20140228)

摘　　要：目的探讨高敏C反应蛋白(hs-CRP)对冠心病介入治疗病人预后的临床价值。方法 2011年5月—2015年5月选择在我院进行诊治的冠心病病人130例,所有病人都给予介入治疗,观察介入前后心功能与hs-CRP变化情况,同时进行术后主要不良心血管事件的随访调查。将冠心病病人根据PCI术前血清C反应蛋白(CRP)水平分为A组(CRP≥3 mg/L)与B组(CRP<3 mg/L)。结果所有病人都介入成功,介入后3个月的左室射血分数(LVEF)值明显高于介入后1个月,且都明显高于介入前,差异有统计学意义(P<0.05)。介入后7 d病人的血清hs-CRP值明显高于介入后3 d,同时都明显高于术前,差异有统计学意义(P<0.05)。130例病人中术后3个月内发生主要不良心血管事件14例,总发生率为10.8%;A组的主要不良心血管事件发生情况明显高于B组(P<0.05);并且A组介入后1个月与介入后3个月的LVEF明显低于B组(P<0.05)。结论冠心病介入治疗成功率高,能有效改善心功能,术前hs-CRP水平对预测主要不良心血管事件有一定价值。Objective To investigate the clinical prognosis values of high-sensitivity C-reactive protein（hs-CRP）guiding interventional therapy for the coronary heart disease（CHD）patients.Methods From May 2011 to May 2015,130 patients with CHD in our hospital were selected for treatment,all patients were given intervention.The cardiac function,serum hs-CRP changes were observed before and after the intervention.According to preoperative serum CRP levels,patients were divided into group A（CRP≥3 mg/L）and group B（CRP3 mg/L）.Results All patients were involved in successful,left ventricular ejection fraction（LVEF）values in postoperative3 months was significantly higher than that in postoperative 1 month（P〈0.05）.The levels of serum hs-CRP in postoperative 7 days was significantly higher than that in postoperative 3 days and before operation（P〈0.05）.There were 14 patients of major adverse cardiovascular events（MACE）occurred within followed-up 3 months,the incidence were 10.8%.The incidence of MACE in group A were significantly higher than that in group B（P〈0.05）.LVEF in postoperative 1 month and 3 months were lower in group A than that in group B（P〈0.05）.Conclusion The interventional therapy for CHD can improve heart function and has higher success rates,but it can contribute to elevate hs-CRP levels in the short term.The preoperative hs-CRP levels can predict MACE after intervention.

关 键 词：冠心病 高敏C-反应蛋白 介入治疗 主要不良心血管事件 

分 类 号：R541.4[医药卫生—心血管疾病] R256.2[医药卫生—内科学]