解毒活血方对急性冠脉综合征病人炎症反应及氧化应激的影响  

Effects of Jiedu Huoxue Prescription on Inflammation and Oxidative Stress in Patients with Acute Coronary Syndrome

作　　者：陈丽萍[1] 陈岩[2] 张强[1] 赵淑贤[1] 苏振杰[1] 

机构地区：[1]黑龙江省牡丹江市第一人民医院,黑龙江牡丹江157011 [2]黑龙江省医院

出　　处：《中西医结合心脑血管病杂志》2016年第6期576-579,共4页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：中华人民共和国科学技术部基金项目(No.2011AA02A111),缺血修饰白蛋白、C反应蛋白、髓过氧化物酶等诊断指标联合应用的研究

摘　　要：目的探讨解毒活血方治疗急性冠脉综合征(ACS)的疗效及机制。方法将84例ACS病人随机分为两组,每组42例,对照组给予抗血小板凝集、血管扩张、降脂等常规西医治疗,观察组在西医治疗基础上加用解毒活血方,每日1剂,持续治疗8周,于治疗前、治疗4周、8周分别检测载脂蛋白B/载脂蛋白A-Ⅰ(ApoB/ApoA-Ⅰ)、高敏C反应蛋白(hs-CRP)、白介素-6(IL-6)、白介素-8(IL-8)、髓过氧化物酶(MPO)、丙二醛(MDA)、超氧化物歧化酶(SOD)变化。结果治疗8周后,观察组ApoB/ApoA-Ⅰ低于对照组(P<0.05);治疗后两组炎症因子及氧化应激产物浓度均较治疗前降低(P<0.05),治疗8周后观察组hs-CRP、IL-6、IL-8低于对照组(P<0.05);治疗4周、8周后,观察组MPO、MDA浓度均低于对照组,而SOD活性则高于对照组,差异有统计学意义(P<0.05或P<0.01)。结论解毒活血方可有效下调ACS病人脂质,缓解炎症反应及氧化应激反应,改善病人预后。Objective To investigate the efficacy and mechanism of Jiedu Huoxue prescription（JHP）for treatment of acute coronary syndrome（ACS）.Methods Eighty-four patients with ACS were randomly divided into two groups：control group（n =42）treated with routine treatment,and treatment group（n=42）treated with JHP and routine treatment for 8 weeks.The levels of apolipoprotein B/apolipoprotein A-Ⅰ（ApoB/ApoA-Ⅰ）,high-sensitivity C-reactive protein（hs-CRP）,interleukin-6（IL-6）,interleukin-8（IL-8）,myeloperoxidase（MPO）,malondialdehyde（MDA）,superoxide dismutase（SOD）were detected before treatment and after four weeks,eight weeks of treatment.Results After 8 weeks of treatment,the level of ApoB/ApoA-Ⅰin treatment group was lower than that in control group（P〈0.05）.After treatment,the levels of inflammatory cytokines and oxidative stress products were decreased in two groups（P〈0.05）.After 8 weeks of treatment,the levels of hs-CRP,IL-6,IL-8 in treatment group was lower than that in control group（P〈0.05）.After 4 weeks and 8 weeks of treatment,the levels of MPO and MDA in treatment group was lower than that in control group while SOD activity in treatment group was higher than that in control group（P〈0.05 or P〈0.01）.Conclusion JHP can down-regulate lipids,relieve inflammation and oxidative stress,improve prognosis in patients with ACS.

关 键 词：急性冠脉综合征 解毒活血方 炎症反应 氧化应激 白细胞介素 

分 类 号：R285.6[医药卫生—中药学]