Efficacy and safety of Yinchenwuling powder for hyperlipidemia: a systematic review and Meta-analysis  

作　　者：Yao Haiqiang Zhang Zengliang Wang Ji Zuo Jiacheng Chen Yu Zhu Libing Li Xiaoke Yang Zheng Wang Zisong Sun Ranran Xu Xuanxuan Li Changming Wu Yanling Li Lingru Wang Qi 

机构地区：[1]Basic Medi-cal College, Beijing University of Chinese Medicine, Beijing100029, China [2]Traditional Chinese Medicine College, in-ner Mongolia Medical University, Hohhot 01011 O, China [3]Department of Nutrition, Chinese-Japan Friend-ship Hospital, Beijing 100029, China

出　　处：《Journal of Traditional Chinese Medicine》2016年第2期135-143,共9页中医杂志（英文版）

基　　金：Supported by the Chinese National Natural Science Foundation Key Project(Identification of the Molecular Signature Contributing to the Susceptibility of Phlegmatic Hygrosis Constitution to Metabolic Syndrome,No.81030064)

摘　　要：OBJECTIVE:To assess the clinical effectiveness and adverse effects of Yinchenwuling powder(YCWLP)in the treatment of hyperlipidemia using Meta-analysis.METHODS:Seven electronic databases were searched for randomized controlled trials designed to evaluate the clinical effectiveness of YCWLP for hyperlipidemia published in any language prior to February 2015.Two reviewers independently identified articles,extracted data,assessed quality,and cross-checked the results.Revman 5.3 was used to analyze the data.RESULTS:Only five randomized controlled trials with poor methodology were included in the analy-sis.The five trials compared YCWLP with conventional lipid-lowering drugs.Meta-analysis indicated that YCWLP was more effective at the levels of total cholesterol and triglycerides,while increasing the level of high-density lipoprotein cholesterol without serious adverse effects.However,it was not more effective than lipid-lowering drugs in reducing low-density lipoprotein cholesterol and improving hemorheology.CONCLUSION:YCWLP appeared to improve lipid levels.However,given the high risk of bias among the trials,we could not conclude that YCWLP was beneficial to patients with hyperlipidemia.More rigorous trials are required to provide stronger evidence for the conclusion.OBJECTIVE： To assess the clinical effectiveness and adverse effects of Yinchenwuling powder（YCWLP）in the treatment of hyperlipidemia using Meta-analysis.METHODS： Seven electronic databases were searched for randomized controlled trials designed to evaluate the clinical effectiveness of YCWLP for hyperlipidemia published in any language prior to February 2015. Two reviewers independently identified articles, extracted data, assessed quality, and cross-checked the results. Revman 5.3 was used to analyze the data.RESULTS： Only five randomized controlled trials with poor methodology were included in the analy-sis. The five trials compared YCWLP with conventional lipid-lowering drugs. Meta-analysis indicated that YCWLP was more effective at the levels of total cholesterol and triglycerides, while increasing the level of high-density lipoprotein cholesterol without serious adverse effects. However, it was not more effective than lipid-lowering drugs in reducing low-density lipoprotein cholesterol and improving hemorheology.CONCLUSION： YCWLP appeared to improve lipid levels. However, given the high risk of bias among the trials, we could not conclude that YCWLP was beneficial to patients with hyperlipidemia. More rigorous trials are required to provide stronger evidence for the conclusion.

关 键 词：HYPERLIPIDEMIAS REVIEW Meta-analy sis Yinchenwuling powder Randomized controlled trials 

分 类 号：R589.2[医药卫生—内分泌]