Evaluation of anti-aphthous activity of decoction of Nicotiana tabacum leaves as a mouthwash： a placebo-controlled clinical study  

作　　者：Siavash Vaziri Mahdi Mojarrab Mohammad Hosein Farzaei Farid Najafi Ali Ghobadi 

机构地区：[1]Department of Infectious Disease, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah 6734667149, Iran [2]Pharmaceutical Sciences Research Center,Kermanshah University of Medical Sciences, Kermanshah 6734667149, Iran [3]Pharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences,Kermanshah 6734667149, Iran [4]Kermanshah University of Medical Sciences,Kermanshah 6734667149, Iran [5]Department of Traditional Pharmacy, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran 1417653761, Iran

出　　处：《Journal of Traditional Chinese Medicine》2016年第2期160-164,共5页中医杂志（英文版）

摘　　要：OBJECTIVE: To determine the effects of decoction derived from the leaves of Nicotiana tabacum(L.)as a mouthwash on minor recurrent aphthous.METHODS: A randomized double-blinded placebo-controlled clinical trial was conducted on 60 patients with minor recurrent aphthous. Treatment comprised of application of tobacco or placebo mouthwash(10 m L 3 times a day) for 5 days. Clinical evaluation included pain level using a visual analog scale and ulcer size on days 1, 3, and 5 were measured. Adverse effects after mouthwash application were recorded, and the oral mucosa was examined by the investigator at each visit.RESULTS: A total of 54 subjects with the mean age(38 ± 10) years fulfilled the study. No minor and major adverse effects were observed. In the treatment group, ulcer pain score was decreased by 79.2%and 93.8% and ulcer size was reduced by 69.1%and 92.2%(days 3 and 5, respectively), which was significantly greater than the control group(P <0.01).CONCLUSION: The decoction prepared with of Nicotiana tabacum leaves, used as mouthwash are well-tolerated and safe, and can be used for the management of recurrent aphthous.OBJECTIVE： To determine the effects of decoction derived from the leaves of Nicotiana tabacum（L.）as a mouthwash on minor recurrent aphthous.METHODS： A randomized double-blinded placebo-controlled clinical trial was conducted on 60 patients with minor recurrent aphthous. Treatment comprised of application of tobacco or placebo mouthwash（10 m L 3 times a day） for 5 days. Clinical evaluation included pain level using a visual analog scale and ulcer size on days 1, 3, and 5 were measured. Adverse effects after mouthwash application were recorded, and the oral mucosa was examined by the investigator at each visit.RESULTS： A total of 54 subjects with the mean age（38 ± 10） years fulfilled the study. No minor and major adverse effects were observed. In the treatment group, ulcer pain score was decreased by 79.2%and 93.8% and ulcer size was reduced by 69.1%and 92.2%（days 3 and 5, respectively）, which was significantly greater than the control group（P 0.01）.CONCLUSION： The decoction prepared with of Nicotiana tabacum leaves, used as mouthwash are well-tolerated and safe, and can be used for the management of recurrent aphthous.

关 键 词：STOMATITIS APHTHOUS Tobacco Pain Ul cer Medicine Traditional Complementary thera pies Mouthwashes 

分 类 号：R276.8[医药卫生—中医五官科学]