益阳颗粒对肾阳虚大小鼠模型的药理作用  

Experimental Study of the Pharmacological Action Effect of Yi-yang Granule on Rat Model and Mouse Model with Deficiency of Kidney-yang

作　　者：赵庆华[1] 李晓娜[1] 

机构地区：[1]华北制药集团新药研究开发有限责任公司,微生物药物国家工程研究中心,河北省工业微生物代谢工程技术研究中心,石家庄050015

出　　处：《黑龙江医药》2016年第1期44-47,共4页Heilongjiang Medicine journal

摘　　要：目的:观察益阳颗粒对肾阳虚大小鼠模型的药理作用。方法:考察益阳颗粒对去势雄性大鼠的生殖系统的影响;采用肌注氢化可的松造成肾阳虚证小鼠模型,考察益阳颗粒的药理作用。结果:益阳颗粒能显著增加去势大鼠的包皮腺、精囊腺-前列腺和肛提肌指数(P<0.01),并能延长阳虚小鼠耐低温游泳时间和精囊腺-前列腺指数(P<0.05)。结论:益阳颗粒对去势大鼠和肾阳虚证小鼠有一定的疗效。Objective： To observe the influence of yi-yang granule on rat model and mouse model with deficiency of kidney-yang. Method： The pharmacological action of the yi-yang granule was evaluated in the castration of the rats and the mouse model with defi- ciency of kidney-yang were made by intramuscular injection of hydrocortisone. Result： The experimental study showed that yi-yang granule at the dose of 2g/kg could increase the organ relative weight of praeputial gland, levator ani muscle, seminal vesicle and pros- tatic gland in castration of the male rats （P〈0.01）. The yi-yang granule at the dose of 4g/kg obviously prolonged survival time in hypo- thermia swimming and increased the organ relative weight of seminal vesicle and prostatic gland in mice with deficiency kidney-yang were made by hydrocortisone （P〈0.05）. Conclusion： It is indicated that yi-yang granule exerts a certain therapeutic effect on male castrated rats and mice with deficiency of kidney-yang.

关 键 词：益阳颗粒 肾阳虚模型 大鼠 小鼠 

分 类 号：R285.5[医药卫生—中药学]