蛹虫草子实体胶囊对S_(180)小鼠抗肿瘤作用的实验研究  

Experiments of antitumor effect of Cordyceps militaris capsules on S_(180) mouselet

作　　者：董祺 高志惠[2] 

机构地区：[1]山东老来寿生物集团股份有限公司,山东济南250014 [2]山东中医药大学,山东济南250355

出　　处：《山东科学》2016年第2期25-29,共5页Shandong Science

基　　金：山东省国际科技合作计划(2012GHZ21903);山东省自然科学基金(ZR2015HM061);山东省科技发展计划(2014GSF118026)

摘　　要：采用小鼠腋下S180实体瘤模型,通过检测抑瘤率、免疫器官重量以及血清NSE、CEA、CA72-4等指标,全面评价蛹虫草子实体胶囊对S180小鼠的抗肿瘤作用。结果表明,蛹虫草子实体胶囊中、高剂量能明显抑制S180实体瘤的生长(P<0.05);高、中、低剂量均可延长S180腹水瘤小鼠的生存时间;高、中、低剂量组均能降低血清NSE的值;中、低剂量组均能增加血清CEA的值;高剂量组能增加血清CA72-4值,而中、低剂量则减少血清CA72-4值。研究认为,蛹虫草子实体胶囊对S180小鼠具有一定的抗肿瘤作用。We employ S180 solid tumor model at the armpit of mouselet to comprehensively evaluate antitumor effect of Cordyceps militaris capsules on S180 mouselet through the test for such parameters as tumor inhibition rate, immune organ weight and serum NSE, CEA and CA72-4. Results show that medium and high dosage Cordyceps military capsule can significantly inhibit the growth of S180 solid tumor （ P 〈 0.05）. High, medium and low dosage Cordyceps military capsule can all extend survival time of S180 ascites sarcoma mouselet. High, medium and low dosage Cordyceps military capsule can all reduce the value of serum neuron specific enolase （NSE）. Medium and low dosage Cordyceps military capsule can increase the value of serum CEA. High dosage Cordyceps military capsule can increase the value of serum CA72-4, but medium and low dosage Cordyceps military capsule can reduce the value of serum CA72-4. These experiments show that Cordyceps militaris capsule has certain antitumor effect on S180 mouselet.

关 键 词：蛹虫草子实体胶囊 S180肉瘤小鼠 抗肿瘤 

分 类 号：R965.1[医药卫生—药理学]