性病门诊梅毒患者治疗后转归情况分析  

Analysis of treatment outcomes of the patients with syphilis in STD clinics

作　　者：赵延明[1] 谢艳光[1] 仲伟麒[1] 张东[1] 金巍[1] 王晓杰[1] 

机构地区：[1]黑龙江省性病防治中心,哈尔滨150001

出　　处：《中国艾滋病性病》2016年第4期279-281,共3页Chinese Journal of Aids & STD

基　　金：黑龙江省卫生厅2013年科研课题项目(2013404)~~

摘　　要：目的研究梅毒血清固定患者与血清转阴患者临床情况的关系。方法选取就诊于黑龙江省性病防治中心性病门诊的梅毒患者197例,借助梅毒患者血清固定调查记录表及血清阴转调查记录表收集资料,进行血清固定与血清转阴患者的临床分析。结果197例梅毒患者主要集中在20-49岁,有37例发生血清固定（占18.78%）,其中一期梅毒血清固定率8.57%,二期梅毒血清固定率11.76%,潜伏梅毒血清固定率27.66%。在临床治疗中,133例应用青霉素治疗者中,形成血清固定19例（14.29%）;25例用头孢曲松钠治疗者中,形成血清固定3例（12.00%）;39例应用多西环素治疗者中,形成血清固定15例（38.46%）。结论潜伏梅毒血清固定率最高,梅毒血清固定发生与疾病分期有关,青霉素与头孢曲松钠治疗本病均有良好疗效,其中青霉素仍为治疗梅毒的首选药物。血清固定与性别、年龄关系不密切。加强对梅毒的早期筛查和及早规范治疗,是减少梅毒血清固定的关键措施。Objective To study the correlation between serofast and seronegative patients.Methods 197 syphilis patients were selected,who received treatment in STD clinics.Data collection and analysis were based on syphilitic serofast patients＇ survey,and the information of sero fixation and seroconversion of patients.Results The 197 cases were mainly at the age of 20-49years.Among them 37 cases had serofast reaction,accounting for 18.78%,with8.57%of primary syphilis,11.76% of secondary syphilis,27.66%of latent syphilis.19cases（14.29%）of sero fixation came from 133 patients treated by penicillin,and 3cases（12.00%）from 25 patients with non-penicillin treatment but ceftriaxone sodium,and 15cases（38.46%）from 39 patients receiving other treatment modalities such as doxycycline.Conclusion Serofixation rate of latent syphilis is the highest,and its occurrence is associated with the stage of disease.Penicillin and ceftriaxone sodium are still the first drugs for syphilis treatment with a good effect.Serofixation is not closely related to gender and age.We must strengthen early screening of syphilis and early standard treatment to reduce the syphilis serofixation.

关 键 词：梅毒患者 血清固定 血清转阴 临床分析 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]