制备2-甲氧亚氨基-2-呋喃乙酸的新方法  

New Method for the Preparation of 2-methoxyimino-2-furylacetic Acid

作　　者：李永伟[1] 王娟[2] 朱智甲[3] 李瑞民[1] 张建[1] 

机构地区：[1]河北常山生化药业股份有限公司,河北石家庄050800 [2]石家庄学院化工学院,河北石家庄050035 [3]上海东华大学化学化工与生物技术学院,上海201620

出　　处：《河北师范大学学报（自然科学版）》2016年第2期153-155,共3页Journal of Hebei Normal University：Natural Science

摘　　要：利用亚硝酸乙酯氧化乙酰呋喃,得到2(2-呋喃基)-2-氧代乙酸,再与甲氧胺盐酸盐缩合,制得2(2-呋喃基)-2-甲氧亚氨基乙酸.通过实验筛选出了最佳反应条件.目标产物经1 HNMR进行了表征.采用该法能够方便地制得2(2-呋喃基)-2-甲氧亚氨基乙酸,并且反应收率高,过程温和,操作简单和三废少.The 2-acetyl furan was first converted to 2-furanyloxoacetic acid with the oxidation of ethyl nitrite.By reacting with methoxyamine hydrochloride,the 2-methoxyimino-2-furylacetic acid was obtained.The reaction temperature and time had been optimized through the experimens.The target products had been identified with 1 HNMR.The method has many advantages,such as high yield,mild process,and simple operation with much fewer waste and pollution.

关 键 词：2(2-呋喃基)-2-甲氧亚氨基乙酸 乙酰呋喃 亚硝酸乙酯 氧化 合成 

分 类 号：O626.11[理学—有机化学]