基于功能性磁共振技术探讨脑卒中后单侧空间忽略患者的发病机制  

Mechanism of unilateral spatial neglect after stroke based on functional magnetic resonance imaging technique

作　　者：王芹[1] 陶静[1] 刘斐雯 宋海燕[1] 梁小凤[1] 陈立典[1] 

机构地区：[1]福建中医药大学,福州市350003

出　　处：《实用医学杂志》2016年第7期1044-1047,共4页The Journal of Practical Medicine

基　　金："十二五"国家科技支撑计划课题(编号:2013BAI10B01)

摘　　要：目的:应用功能性磁共振成像技术对脑卒中后单侧空间障碍(USN)患者及非USN患者进行对比研究,观察两组患者大脑功能连接变化,初步探讨USN患者功能连接的发病机制。方法 :选取8例USN患者(USN组)及8例无USN的患者(对照组),收集功能性磁共振成像数据,采用独立成分分析方法进行数据处理。结果:与对照组比较,USN组患者额顶网络与左额、颞叶等脑区功能连接升高,与右扣带回、楔前叶、颞中/前回等脑区功能连接降低,且与行为学量表分数高度相关。结论:脑区之间功能连接的异常可能与USN有关,本研究结果有助于理解脑卒中后USN的发病机制。Objective To explore the mechanism of brain function connection（FC） by observing the changes of unilateral spatial neglect（USN） and non-USN patients, using functional magnetic resonance imaging technique（f MRI）. Methods 8 USN and 8 control patients participated in the study and f MRI data were collected.The data was analyzed by independent component analysis method. Results USN group showed increased FC in the left frontal / temporal lobeas well and decreased FC in the right cingulate gyrus, precuneus, temporalgyrus compared with control group. These were highly related to behavioral scores. Conclusions Abnormal brain function connection may be related to USN. The findings were helpful for understanding the potential mechanism underlying of USN.

关 键 词：卒中 单侧空间忽略 额顶网络 功能性磁共振 独立成分分析 

分 类 号：R445.2[医药卫生—影像医学与核医学] R743.3[医药卫生—诊断学]