化痰活血降气方治疗慢性阻塞性肺疾病的临床试验  

Clinical tests of huatan Huoxue Jiangqi prescription in treatment of chronic obstructive pulmonary disease

作　　者：张念[1] 殷人易[1] 袁文胜[1] 孙洁民[1] 夏倩[1] 黄莺[1] 

机构地区：[1]武汉市第一医院,430022

出　　处：《实用医学杂志》2016年第7期1176-1179,共4页The Journal of Practical Medicine

基　　金：湖北省卫生和计划生育委员会科研项目(编号:WJ2015MB238);武汉市卫生和计划生育委员会项目(编号:WZ14B04)

摘　　要：目的:探讨化痰活血降气方治疗慢性阻塞性肺疾病急性加重期(AECOPD)的临床疗效。方法:将123例AECOPD患者随机分为治疗组和对照组,两组均给予西医治疗,治疗组加用化痰活血降气方中药治疗,比较两组治疗后的证候疗效、临床症状评分、慢阻肺患者自我评估测试(CAT)评分、改良版英国医学研究委员会呼吸问卷(m MRC)分级、血清纤维蛋白原(FIB)及C-反应蛋白(CRP)水平,对比两组治疗前后肺功能水平的变化。结果:治疗组治疗后的证候疗效明显优于对照组,治疗组治疗后的临床症状评分、CAT评分、m MRC分级较治疗前明显改善(P<0.05),且与对照组相比,临床症状评分、CAT评分有显著差异(P<0.05);治疗组治疗后肺功能(包括FEV1、FEV1占预计值的百分比、FEV1/FVC)明显提高(P<0.05),与对照组相比有显著差异(P<0.05);治疗组治疗后血清FIB及CRP水平明显下降(P<0.05),与对照组相比有显著差异(P<0.05)。结论 :化痰活血降气方治疗AECOPD安全有效。Objective To investigate the Huatan Huoxue Jiangqi prescription in treating AECOPD clinical curative effect. Methods 123 patients with AECOPD were randomly divided into the treatment group and the control group. The two groups were treated with western medicine, and the treatment group added with Chinese herbal medicine treatment with Huatan Huoxue Jiangqi prescription. The syndrome effect, clinical symptom score, CAT score, m MRC classification, lung function, the serum FIB and CRP levels were obtained to evaluate the efficacy of the two groups before and after treatment. Results The syndrome effect of the treatment group was significantly better than that of the control group. Compared with the control group, there was significant difference between traditional Chinese medicine syndrome score, CAT score（P〈0.05）; Lung function（including FEV1, FEV1%, FEV1/ FVC） was significantly improved in the treatment group after treatment（ P〈0. 05）.The serum FIB and CRP levels decreased significantly in the treatment group compared with the control group（P〈0.05）. Conclusion Huatan Huoxue Jiangqi prescription has reliable effets on treating AECOPD.

关 键 词：肺疾病 慢性阻塞性 化痰活血降气方 纤维蛋白原 C-反应蛋白 

分 类 号：R249[医药卫生—中医临床基础] R259[医药卫生—中医学]