血管紧张素转化酶抑制剂在冠心病心力衰竭患者新发房颤中的预防作用  

Prevention Application of Angiotensin Converting Enzyme Inhibitors in new Onset Atrial Fibrillation of Patients with Coronary Heart Disease

作　　者：黎洁雯[1] 

机构地区：[1]中山市人民医院,中山528400

出　　处：《血栓与止血学》2016年第2期140-143,共4页Chinese Journal of Thrombosis and Hemostasis

摘　　要：目的探讨血管紧张素转化酶抑制剂在冠心病心力衰竭患者新发房颤中的预防作用。方法随机选取2012年5月至2015年5月我院心血管内科收治的80例冠心病心力衰竭患者,依据随机数字表法分这些患者为两组,即研究组(n=40)和对照组(n=40)。给予对照组患者常规治疗,给予研究组患者常规治疗基础上血管紧张素转化酶抑制剂治疗,然后对两组患者的一般资料、治疗药物和实验室指标、新发房颤发生情况和维持窦性心律情况进行统计分析。结果研究组患者的射血分数显著低于对照组(P<0.05),心肌梗死、糖尿病比例均显著高于对照组(P<0.05),应用洋地黄、阿司匹林比例均显著高于对照组(P<0.05),新发房颤发生率10.0%(4/40)显著低于对照组27.5%(11/40)(P<0.05),维持窦性心律比例90.0%(36/40)显著高于对照组72.5%(29/40)(P<0.05)。结论血管紧张素转化酶抑制剂能够有效预防冠心病心力衰竭患者新发房颤。Objective To investigate the prevention application of angiotensin converting enzyme inhibitors（ ACEI） in new onset atrial fibrillation of patients with coronary heart disease. Methods 80 cases of patients with coronary heart disease who were treated in cardiovascular medicine of our hospital from May 2012 to May 2015 were randomly selected,these patients were divided into two groups according to a random number table,the study group（ n = 40） and control group（ n = 40）. The control group were given routine treatment,while the study group were given the angiotensin-converting enzyme inhibitors based on conventional treatment,and then the general information,drugs and laboratory tests,the incidence of new-onset atrial fibrillation and maintenance of sinus rhythm of the two groups were statistically analyzed. Results The ejection fraction of the study group was significantly lower（ P〈0. 05）,the proportion of myocardial infarction,diabetes were significantly higher（ P〈0. 05）,the proportion of digitalis,aspirin were significantly higher（ P〈0. 05）,the incidence of new onset atrial fibrillation 10. 0%（ 4 /40） was significantly lower than the control group27. 5%（ 11 /40）（ P〈0. 05）,the proportion of maintenance of sinus rhythm 90. 0%（ 36 /40） was significantly higher than the control group 72. 5%（ 29 /40）（ P〈0. 05）. Conclusion ACEI can effectively prevent new onset atrial fibrillation of patients with coronary heart disease.

关 键 词：血管紧张素转化酶抑制剂 冠心病心力衰竭 新发房颤 预防 

分 类 号：R541.4[医药卫生—心血管疾病]