糖尿病肾病患者血清同型半胱氨酸、胱抑素C及D二聚体联合检测的临床意义  

Clinical Significance of Combined Detection of Serum Homocysteine,Cystatin C and D-dimer in Patients with Diabetic Nephropathy

作　　者：陈峻[1] 徐升强[1] 曹文操[1] 

机构地区：[1]武汉市第一医院检验科,武汉430022

出　　处：《血栓与止血学》2016年第2期159-160,164,共3页Chinese Journal of Thrombosis and Hemostasis

摘　　要：目的为探讨糖尿病肾病(DN)患者血清同型半胱氨酸(Hcy)、胱抑素C(Cys C)和D-二聚体(D-D)联合检测的临床意义。方法采用日本OLYMPUS公司AU2700全自动生化分析仪及Sysmex CS2000 i全自动血凝仪对160例DN患者及140例健康体检者血清Hcy、Cys C和D-D水平分别进行检测并对结果进行比较。结果 DN患者血清Hcy、Cys C和D-D水平明显高于健康对照者,差异有统计学意义(P<0.01)。结论血清Hcy、Cys C和D-D联合检测对DN早期诊断、疗效监测、预后判断具有一定的临床意义。Objective To investigate the serum homocysteine（ Hcy）,Cystatin C（ Cys C） and D-dimer（ D-D） clinical significance in patients with diabetic nephropathy（ DN） combined detection. Methods using Japan OLMPUS company AU2700 automatic biochemical analyzer and Sysmex CS2000 i automatic blood coagulation analyzer for 160 cases of diabetic nephropathy（ DN） patients and 140 cases healthy persons serum homocysteine（ Hcy）,cystatin C（ Cys C） and D-dimer（ D-D） levels were respectively detected and the results were compared. Results Diabetic nephropathy（ DN） patients with homocysteine（ Hcy）,cystatin C（ Cys C） and Ddimer（ D-D） levels were significantly higher than healthy controls,the difference was statistically significant（ P〈0. 01）. Conclusion The serum homocysteine（ Hcy）,cystatin C（ Cys C） and D-dimer（ D-D） combined detection of diabetic nephropathy（ DN） in early diagnosis,curative effect monitoring and prognosis judgment has certain clinical significance.

关 键 词：糖尿病肾病 同型半胱氨酸 胱抑素C D二聚体 

分 类 号：R446[医药卫生—诊断学]