糖尿病周围神经病变生物学标志物的临床研究进展  

Advances in biomarkers for diabetic peripheral neuropathy

作　　者：李璐[1] 王从容[1] 

机构地区：[1]上海交通大学附属第六人民医院内分泌代谢科,上海市糖尿病研究所,上海市糖尿病重点实验室,上海市糖尿病临床医学中心,上海200233

出　　处：《中华老年多器官疾病杂志》2016年第4期312-316,共5页Chinese Journal of Multiple Organ Diseases in the Elderly

基　　金：国家自然基金面上项目（81170760）;上海市金山区科学技术创新基金（2011-3-16）

摘　　要：糖尿病周围神经病变（DPN）是糖尿病最常见的慢性并发症之一，可导致足部溃疡、坏疽，甚至截肢，对患者的生活质量造成极大影响。DPN的发病机制复杂。近年来，针对DPN发病各个环节的生物学标志物的研究取得了一定进展。本文以DPN的病理生理改变及发病机制为出发点，主要从神经组织损伤、内皮功能紊乱、氧化应激和炎症4个方面综述DPN的潜在生物学标志物。Diabetic peripheral neuropathy （DPN）, one of the most common chronic complications of diabetes, can lead to foot ulceration, gangrene, and even limb amputation, and impose great impact on patients＇ quality of life. Its pathogenetic mechanism is very complicated. In recent years, certain advances have been taken in identifying biomarkers at different stages in the pathogenesis of DPN. This review summarized the potential blood biomarkers of DPN from the aspects of nerve injury, endothelial dysfunction, oxidative stress as well as inflammation based on the pathology and pathogenesis of DPN.

关 键 词：糖尿病周围神经病变 生物学标志物 发病机制 

分 类 号：R587.1[医药卫生—内分泌] R446[医药卫生—内科学]