生髓育麟汤对实验性少、弱精子大鼠附睾精子质量的影响  

Effect of the Shengsui Yulin Decoction on the sperm quality in rats with oligospermatism

作　　者：古宇能[1] 王全[1] 陈德宁[1] 黄忠旺[1] 廖红珠 

机构地区：[1]广东省深圳市中医院男科,广东深圳518000 [2]广州中医药大学第一临床医学院,广东广州510405

出　　处：《中国医药导报》2016年第11期22-26,共5页China Medical Herald

基　　金：广东省中医药局建设中医药强省科研课题(20151087)

摘　　要：目的观察生髓育麟汤对少、弱精子大鼠附睾精子质量的影响。方法 60只大鼠按照常规饲养方法饲养,1周后随机抽出10只大鼠编入正常对照组,另外50只予雷公藤多苷片20 mg/(kg·d)灌胃26 d。造模完毕后随机抽取10只编入造模组处死,将剩下的40只大鼠随机分为4组:生髓育麟汤高剂量组[20 m L/(kg·d)]、低剂量组[10 m L/(kg·d)]、五子衍宗丸组以及不给予任何药物,只给予正常食物和水的观察对照组,每组各10只。实验结束后获取大鼠附睾精子对各组大鼠的精子质量进行分析。结果生髓育麟汤能明显增加精子密度、前向运动精子比例、精子活动率,并且随着浓度的增加,效果更显著,此外,生髓育麟汤还能改善精子运动特征参数;生髓育麟汤低剂量组、生髓育麟汤高剂量组与观察对照组比较,差异均有高度统计学意义(P<0.01)。结论生髓育麟汤能改善少、弱精子大鼠附睾中的精子质量。Objective To study the effect of Shengsui Yulin Decoction on the sperm quality in rats with oligospermatism. Methods Sixty rats were fed by normol way for a week, then fifty rats oligospermatism models been made by GTW. Ten rats were killed as models after molding, the other 40 rats were equally divided into four groups： the highdose Shengsui Yulin Decoction group [20 m L/（kg·d）], the low-dose Shengsui Yulin Decoction group [10 m L/（kg·d）],Wu Zi Yan Zong Tablets group and the observation control group only feed by water and food. The sperm from the rats epididymis was extracted and sperm quality of each group was detected. Results Sperm density, proportion of progressive sperm, spermatozoal motivity were increased by Shengsui Yulin Decoction, and the therapeutic effect was increased with the increasing of the concentration of Shengsui Yulin Decoction, and the sperm motion parameters were improved by Shengsui Yulin Decoction; compared with observation control group, those indexes of the high-dose Shengsui Yulin Decoction group and the low-dose Shengsui Yulin Decoction group had statistically significant difference（P〈0.01）.Conclusion Shengsui Yulin Decoction can improve the sperm quality of the rat testis with oligospermatism.

关 键 词：生髓育麟汤 少、弱精子症 大鼠 动物实验 

分 类 号：R271.14[医药卫生—中医妇科学]