辽宁地区成年体检人群ALT和AST季节性变异的研究  

Study on the Seasonal Variation of Aminotransferase for Population of Liaoning

作　　者：穆润清[1] 田文[1] 

机构地区：[1]中国医科大学附属第一医院检验科

出　　处：《现代检验医学杂志》2016年第2期32-34,38,共4页Journal of Modern Laboratory Medicine

摘　　要：目的基于辽宁地区大样本体检人群数据，分析转氨酶的季节性变异，评估季节性变异对人群筛查的影响。方法研究对象来自2009～2011年中国医科大学附属第一医院的20～79岁体检人群。进行性别分组并对数据进行筛选，将三年的相同月份数据叠加后，分析血清天门冬氨酸氨基转移酶（AST）和丙氨酸氨基转移酶（ALT）月均值的周期性变化规律，统计分析ALT，AST月均值间的差异，评估季节性水平变化对结果判断的影响。结果共提取167496份测试结果，ALT男性和女性的月均值变异系数分别为4．7％和3．9％，月均值最大变化幅度分别为14．4％和11．2％；AST男性和女性月均值的变异系数分别为2．5％和2．6％，月均值最大变化幅度分别为7．6％和9．0％。无论男性还是女性，转氨酶水平较高和水平较低的连续三个月的均值间差异有统计学意义（P〈0．001）。两个三月组的转氨酶水平变化导致人群超过参考区间上限的比例出现差异：ALT变化1．8％（男性），1．3％（女性）；AST变化0．3%（男性），0．5％（女性）。结论ALT和AST有明显的季节性变异，基于转氨酶参考区间进行正常人群筛查时应注意将季节性因素考虑其中。Objective This study analyzed the seasonal variation of aminotransferase in population of Liaoning,and evaluated the effect of the screening efficiency at physical examination. Methods The data of aspartate aminotransferase （AST） and alanine aminotransferase （ALT） were extracted from the physical examination population database of the First Affiliated Hospital of China Medical University （age：20-79 years）. After filtering out the data for this study by gender,we aggregated the same month data of three years. The variation of monthly means were studied by the one-way analysis of variance with thinking of the influencing factors of gender. Tried to seek the clinical significance through the variation of the medical screening rate. Results Weed got a total of 167 496 test results of ALT and AST. For ALT, the coefficient of variation （CV） of monthly mean for male and female were 4.7% and 3.9 %, and the mean maximum change range for male and female were 14.4% and 11.2% respectively. For AST,the CVof monthly mean for male and female were 2.5% and 2.6% ,and the mean maximum change range for male and female were 7.6 % and 9.0% respectively. There were significant differences between the two groups with different levels of three monthly means （P〈0. 001）. Conclusion ALT and AST were observed to show a significant seasonal variations. These seasonal variations should be taken into consideration when screened the population of physical examination by reference intervals. Keywords： alanine aminotransferase ; aspartate aminotransferase ; biological variation ; seasonal variations

关 键 词：丙氨酸氨基转移酶 天门冬氨酸氨基转移酶 生物学变异 季节性变异 

分 类 号：R446.112[医药卫生—诊断学]