骨细胞凋亡在酒精性股骨头缺血性坏死中的作用  

Apoptosis of bone cells in alcohol-induced osteonecrosis of femoral head

作　　者：黎金焕 陈跃平[2] 

机构地区：[1]广西中医药大学,广西壮族自治区南宁市530001 [2]广西中医药大学附属瑞康医院骨科,广西壮族自治区南宁市530011

出　　处：《中国组织工程研究》2016年第15期2241-2247,共7页Chinese Journal of Tissue Engineering Research

基　　金：广西科技厅重点项目(2015jj AA40148):ZIP1转染骨髓间充质干细胞对酒精性股骨头坏死的保护作用机制研究;广西卫生厅项目(S201419-05):Zip1转染骨髓间充质干细胞结合蚕丝蛋白支架对酒精性股骨头坏死的保护作用机制研究;广西中医药大学项目(J13167(7)):2014年校级培育学科-骨外科学~~

摘　　要：背景:目前对酒精性股骨头缺血坏死仍缺乏行之有效的保髋疗法,病变晚期股骨头塌陷影响髋关节功能的患者只能选择人工髋关节置换。明确酒精性股骨头缺血坏死的发病机制,对股骨头缺血坏死保髋治疗有重要意义。目的:综述近年来国内外有关骨细胞凋亡学说在酒精性股骨头缺血坏死发病机制中的研究进展,为探究酒精性股骨头缺血坏死的治疗方法提供理论依据。方法:由第一作者应用计算机检索PubMed数据库及Embase数据库,在标题和全文中以"Osteonecrosis of Femoral Head and apoptosis"或"bone cell,apoptosis,gene,signal"或"osteonecrosis,alcohol"为检索词,纳入与骨细胞凋亡在酒精诱导股骨头缺血坏死发病机制中作用相关的研究文章。排除重复及较陈旧的文献。共40篇外文文献符合标准。结果与结论:近年来,酒精性股骨头缺血坏死的发病机制学说中的骨细胞凋亡学说得到越来越多人的认同,逐步成为人们研究酒精性股骨头缺血坏死发病机制的焦点。骨细胞凋亡在酒精性股骨头缺血坏死的发病机制中发挥着重要的作用。p53、B细胞淋巴瘤家族、肿瘤坏死因子、半胱氨酸天冬氨酸蛋白水解酶等多种与骨细胞凋亡相关的基因是调控骨细胞凋亡的关键。但由于酒精性股骨头缺血坏死发病机制的复杂性,目前人们对酒精诱导骨细胞凋亡导致的股骨头缺血坏死在基因水平上的研究虽然取得了一定的进展但仍相对缺乏。BACKGROUND： Currently, there is a lack of effective hip preserving therapy in patients with alcohol-induced osteonecrosis of femoral head. Artificial hip replacement is the only choice for the patients whose function of the hip joint is affected by the collapse of the femoral head in the late stage. Therefore, to understand the pathogenesis of alcohol-induced osteonecrosis of femoral head is of great significance for the effective hip preserving therapy in patients. OBJECTIVE： To review the research progress in apoptosis of bone cells in the pathogenesis of alcohol-induced osteonecrosis of femoral head both at home and abroad in recent years, so as to provide a theoretical basis for the study of the treatment of alcohol-induced osteonecrosis of femoral head. METHODS： PubMed and Embase databases were retrieved by the first author using computer to search relevant articles addressing the effect of apoptosis of bone cells in the pathogenesis of alcohol-induced osteonecrosis of femoral head. The keywords were ＂osteonecrosis of femoral head and apoptosis＂, ＂bone cell, apoptosis, gene, signal＂ or ＂osteonecrosis, alcohol＂in the title and the full text. Repetitive and old literatures were excluded, and finally 40 foreign language articles were included in result analysis. RESULTS AND CONCLUSION： In recent years, the theory of apoptosis of bone cells in the pathogenesis of alcohol-induced osteonecrosis of femoral head has been gradually recognized and has become the focus of research on the pathogenesis of alcohol-induced osteonecrosis of femoral head. Apoptosis of bone cells plays an important role in the pathogenesis of alcohol-induced osteonecrosis of femoral head. Various genes, such as p53, Bcl-2 family, tumor necrosis factor, Caspase, are crucial to control the apoptosis of bone cells. Although we have made some progresses at the gene level, there is still a lack of relevant studies on alcohol-induced osteonecrosis of femoral head due to the complexity of pathogenesis.

关 键 词：股骨头坏死 细胞凋亡 基因 组织工程 组织构建 骨组织工程 酒精 骨细胞凋亡 

分 类 号：R318[医药卫生—生物医学工程]