末端病与细胞外基质:骨腱结合部重要蛋白及酶类的关系尚需深入研究  

Tendinopathy and the extracellular matrix: to deeply study the key proteins and enzymes in the bone-tendon junction

作　　者：刘春雨[1] 韩小燕[1] 王琳[2] 

机构地区：[1]玉林师范学院体育学院,广西壮族自治区玉林市537000 [2]北京体育大学,北京市100084

出　　处：《中国组织工程研究》2016年第15期2265-2272,共8页Chinese Journal of Tissue Engineering Research

基　　金：广西高校人文社会科学研究项目(YB2014312);2009玉林师范学院院级重点项目(2009YJZD15)~~

摘　　要：背景:近年来,关于末端病的相关研究正逐渐成为运动医学和康复领域的研究热点,而细胞外基质在末端病的发生、发展和愈合过程中起着不可忽视的作用。目的:探讨末端病和细胞外基质间的关系。方法:检索中国期刊网全文数据库(中国知网CNKI)、维普数据库、中国生物医学文献数据库(CBM)、中国医药学位论文全文数据库(万方)及PubMed数据库和Embase医药数据库。从胶原、蛋白聚糖、糖蛋白以及基质重塑几方面入手,检索了2000年以来一些相关的研究成果并进行了综述。结果与结论:分析表明,末端病发生后,无论是胶原、蛋白聚糖、糖蛋白以及相关的酶类都发生明显的变化,这些指标的变化又影响着末端病的重建和修复过程。目前的研究大多集中在肌腱部分,关注骨腱结合部的研究相对较少,而且许多重要蛋白及酶类与末端病的关系、以及运动干预效果的研究仍不够深入。BACKGROUND： In recent years, research on tendinopathy is becoming a hot topic in the sports medicine and rehabilitation, and the extracellular matrix plays a considerable role in the occurrence, development and healing of tendinopathy. OBJECTIVE： To explore the relationship between tendinopathy and the extracellular matrix. METHODS： CNKI, VIP, CBM, Wanfang, PubMed and Embase were retrieved for articles related to collagen, protein, glycoprotein and matrix remodeling published since 2000. RESULTS AND CONCLUSION： After tendinopathy, there are obvious changes in collagen, proteoglycans, glycoprotein and related enzymes; and these changes also affect the reconstruction and repair of tendinopathy. Currently, most of researches focus on the tendon rather than the bone-tendon junction. This means that there are no in-depth studies on the correlation between many important proteins and tendinopathy, and the effects of exercise intervention.

关 键 词：腱 细胞外基质 运动医学 组织构建 组织工程 末端病 腱病 基质重塑 

分 类 号：R318[医药卫生—生物医学工程]