内皮祖细胞与高血压病的应用研究进展  

Application and progress in endothelial progenitor cells in hypertension

作　　者：李文华[1] 张群辉[1] 戎浩[1] 蔡鹏[1] 袁东亚[1] 

机构地区：[1]西藏民族大学医学部,陕西省咸阳市712082

出　　处：《中国组织工程研究》2016年第15期2273-2280,共8页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金项目(81360299)~~

摘　　要：背景:内皮细胞结构和功能的改变是多种心血管疾病的共同病理基础。现已证实,高血压、冠心病等患者内皮结构和功能严重受损。目的:试图从血管内皮祖细胞角度,探索治疗高血压的新方法。方法:检索PubMed数据库和万方数据库,以关键词"hypertension,EPCs"和"高血压病,内皮祖细胞"进行文献检索,按相关性进行排序最终获得近200余篇英文文献,100余篇中文文献,最后筛选出49篇符合标准的文献。结果与结论:内皮祖细胞的分化和增殖能力较强,调控内皮祖细胞向内皮细胞分化,为高血压病治疗提供一些证据,从而为进一步临床诊疗高血压病提供新的应用前景。BACKGROUND： Structural and functional changes of endothelial cells are the common pathological basis of cardiovascular disease. Severe structural and functional damage of endothelial cells are found in patients with hypertension or coronary heart diseases. OBJECTIVE： To explore a new treatment method for hypertension from the perspective of vascular endothelial progenitor cells. METHODS： PubMed and Wanfang databases were retrieved using the keywords ＂hypertension, EPCs＂ and approximately relevant 200 English and 100 Chinese literatures were obtained. Forty-nine eligible literatures were screened finally. RESULTS AND CONCLUSION： Endothelial progenitor cells have strong differentiation and proliferation capacities. This review may provide a new insight into potential sources of cells for diagnosis and treatment of hypertension.

关 键 词：内皮细胞 高血压 组织工程 组织构建 内皮祖细胞 应用 国家自然科学基金 

分 类 号：R318[医药卫生—生物医学工程]