富血小板纤维蛋白与胶原膜修复牙龈缺损创面的能力  

Platelet-rich fibrin versus collagen membrane in the repair of gingival defects

作　　者：董露[1] 肖琼 杨琴秋[3] 孙勇[1] 陈红亮[1] 

机构地区：[1]解放军成都军区机关医院口腔科,四川省成都市610041 [2]重庆拜博口腔医院管理有限公司九龙坡口腔医院,重庆市400000 [3]遂宁市第一人民医院口腔科,四川省遂宁市629000

出　　处：《中国组织工程研究》2016年第16期2340-2346,共7页Chinese Journal of Tissue Engineering Research

基　　金：成都军区"十二五"科研面上项目(C14050)~~

摘　　要：背景:前期实验中发现富血小板纤维蛋白具有良好的诱导牙龈软组织修复再生的能力。目的:观察富血小板纤维蛋白膜与胶原膜对牙龈软组织愈合的影响,评价富血小板纤维蛋白膜诱导牙龈软组织缺损修复再生的能力。方法:选因各种原因需要拔除前磨牙或磨牙同期进行位点保存的患者22例(前磨牙2颗,磨牙20颗),随机分为2组,22个软组织缺损区域,拔牙窝内植入Bio-Oss,表面覆盖富血小板纤维蛋白膜或海奥胶原膜。通过追踪植入Bio-Oss后牙龈创面的愈合时间和植入Bio-Oss后1,2周的创面愈合率,评价富血小板纤维蛋白促进牙龈组织愈合的能力。结果与结论:①富血小板纤维蛋白组愈合时间为(12.17±2.25)d,胶原膜组愈合时间为(17.30±2.58)d;植入Bio-Oss后1,2周富血小板纤维蛋白组愈合率明显高于胶原膜组。②结果说明,相同时间节点时富血小板纤维蛋白促进牙龈软组织的愈合能力明显优于胶原膜,达到相同愈合状态时富血小板纤维蛋白组所需时间明显短于胶原膜组。BACKGROUND： Previous studies have found that platelet-rich fibrin has a good ability to induce gingival soft tissue repair and regeneration. OBJECTIVE： To observe the effects of platelet-rich fibrin versus collagen membrane on gingival soft tissue healing, and to evaluate the ability of platelet-rich fibrin to repair gingival defects. METHODS： Twenty-two patients（2 premolar teeth and 20 molars） scheduled for premolar or molar removal or ridge preservation due to various reasons were selected and randomized into two groups. Bio-Oss was implanted into the extraction socket followed by covering with platelet-rich fibrin or collagen membrane. Healing time and healing rate of gingival defects were detected to evaluate the ability of platelet-rich fibrin to promote gingival tissue healing at 1-2 weeks after Bio-Oss implantation. RESULTS AND CONCLUSION： The healing time was（12.17±2.25） days in the platelet-rich fibrin group and（17.30±2.58） days in the collagen group. The healing rate of the platelet-rich fibrin group was notably higher than that in the collagen membrane group at 1 and 2 weeks after Bio-Oss implantation. These findings indicate that platelet-rich fibrin is better than collagen membrane to improve the healing of gingival soft tissues with a shorter healing time.

关 键 词：牙龈 软组织损伤 伤口愈合 组织工程 生物材料 材料相容性 富血小板纤维蛋白 脱细胞真皮基质 牙龈软组织缺损 创面愈合 

分 类 号：R318[医药卫生—生物医学工程]