新型纳米材料无定形磷酸钙药物支架置入小型猪冠状动脉后的生物相容性  

A novel amorphous calcium phosphate drug-eluting stent: its biocompatibility after implantation into mini-swine coronary artery

作　　者：谭峥[1] 李莉[1] 马燚[1] 

机构地区：[1]河北医科大学唐山临床医学院河北医科大学附属唐山工人医院河北省唐山市工人医院,河北省唐山市063000

出　　处：《中国组织工程研究》2016年第16期2354-2359,共6页Chinese Journal of Tissue Engineering Research

基　　金：河南省省属科研机构2005年度研究专项基金项目(0541130601)~~

摘　　要：背景:以往冠状动脉植入支架大多为聚左旋乳酸,但存在早期支撑力不足的问题,且会产生一定的酸性产物,导致血管局部出现炎性反应。目的:探讨新型纳米材料无定形磷酸钙药物支架置入小型猪冠状动脉后的生物相容性。方法:20只小型猪随机等分为观察组和对照组,对动物右侧股动脉予以逐层分离,分别置入新型生物全降解支架和聚左旋乳酸支架。结果和结论:①支架置入后即刻进行冠状动脉造影:可见2组支架置入血管管腔均处于良好的通畅状态;②置入后4周冠状动脉造影复查:管腔通畅,未出现支架血栓形成与管腔狭窄,2组情况接近;③置入前和置入后4周2组动物血液相关指标检测:C-反应蛋白水平接近。置入后4周,观察组小型猪心脏组织中的淋巴细胞数量与炎症积分均显著低于对照组,而新生内膜面积和面积狭窄百分比与对照组接近;④结果提示新型纳米材料无定形磷酸钙药物支架置入小型猪冠状动脉后具有良好的生物相容性。BACKGROUND： As previously reported, poly-L-lactic acid stents have been mostly used as coronary artery stents, but this stent has a lack of early support force and produces some acidic products that will induce local vascular inflammatory reactions. OBJECTIVE： To explore the biocompatibility of a novel amorphous calcium phosphate drug-eluting stent, after implantation into mini-swine coronary artery. METHODS： Twenty mini-swine were randomly equivalently divided into observation group and control group. The right femoral arteries of animals were separated layer by layer and the new type of biodegradable stent and poly-L-lactic acid stent were implanted, respectively. RESULTS AND CONCLUSION： The vessel lumes in the two groups were smooth and unobstructed showed by coronary artery angiography immediately after implantation. At 4 weeks after implantation, the coronary angiography showed the patency of vessel lumens with no stent thrombosis and stenosis in both two groups. The C-reactive protein levels in the two groups had no significant differences before and 4 weeks after stent implantation. At 4 weeks after implantation, the number of lymphocytes and inflammatory score in the observation group were significantly higher than those in the control group, but the neointimal area and percentage of stenosis area had no significant difference between the two groups. These results indicate that the novel amorphous calcium phosphate drug-eluting stent after implantation into mini-swine coronary artery has good biocompatibility.

关 键 词：磷酸钙类 淋巴细胞 组织工程 生物材料 纳米材料 冠状动脉 无定形磷酸钙 药物支架 猪 生物相容性 可降解材料 

分 类 号：R318[医药卫生—生物医学工程]