家蚕作为人类疾病模型与用于药物筛选的研究进展及展望  

Progress and perspective of silkworm as a model of human diseases for drug screening

作　　者：陈敏[1] 宋江波[1] 李知泉 唐冬梅[1] 童晓玲[1] 代方银[1] 

机构地区：[1]西南大学生物技术学院,家蚕基因组生物学国家重点实验室,农业部蚕桑功能基因组与生物技术重点实验室,重庆400716

出　　处：《药学学报》2016年第5期690-697,共8页Acta Pharmaceutica Sinica

基　　金：国家863计划项目(2013AA102507);国家自然科学基金面上项目(31372379);现代农业产业技术体系项目(CARS-22-SYZ22)

摘　　要：家蚕(Bombyx mori)具有饲养容易、子代多、生命周期短、大小适中易于实验操作、遗传背景清楚、突变资源丰富等优点,长期被用作实验遗传学材料,被确定为鳞翅目昆虫的研究模式。家蚕也逐渐成为人类疾病模型和药物筛选的新型实验动物。近期的相关研究表明,在家蚕丰富的遗传资源中,存在着诸多人类遗传疾病模型,如苯丙酮尿症模型、帕金森病模型和海-普综合征模型等。家蚕在人类病原微生物致病机制探究方面也做出了重要贡献。此外,家蚕能够用于药代动力学研究及系统地评价药效及药物安全性,并且能够实现高通量药物筛选,可大大缩短新型药物的研发周期。本文综述了家蚕作为疾病模型及用于药物筛选的研究进展,分析了其开发前景,以期能够帮助人们全面地了解家蚕在新药研发中的作用,为大规模开展基于家蚕人类疾病模型的药物筛选提供参考。As a typical representative of Lepidopteran insects,the silkworm,Bombyx mori,has numerous advantages,such as simple husbandry,highly prolific nature,short generation time,easily handled to be operated with moderate body size,clear genetic background and abundant mutation resources.Silkworm has not only been studied by the geneticists,but also been used as a new laboratory animal model of human disease and drug screening.There is a plenty of genetic resources in silkworm,some of which could be used as models of human genetic diseases,such as Phenylketonuria,Parkinson＇s disease,Hermansky-Pudlak syndrome and so on.Silkworm has also played a significant role in the study of pathogenesis of human pathogenic microorganisms.Moreover,silkworm could be used to evaluate the pharmacokinetic/pharmacodynamics properties and safety of a new drug comprehensively and systematically.At the same time,it can be used in the high throughput drug screening assays to shorten the period of the new drug research and development.This review summarizes that the silkworm is an excellent model in the drug screening assays,and has a potential in application to the large-scale drug screening.

关 键 词：家蚕 实验动物 疾病模型 药物筛选 药物评价 

分 类 号：R915[医药卫生—微生物与生化药学]