萧山区儿童过敏原与变态反应性疾病关系现状调查分析  

Investigation of the relationship between allergens and allergic diseases in Xiaoshan children

作　　者：潘开宇[1] 章锃瑜[2] 邵波[1] 俞涟芳[1] 梁友方[3] 詹建华[1] 

机构地区：[1]杭州市萧山区第一人民医院儿科,浙江杭州311201 [2]杭州市萧山区第一人民医院科教科,浙江杭州311201 [3]杭州市萧山区第一人民医院检验科,浙江杭州311201

出　　处：《中国现代医生》2016年第10期125-128,共4页China Modern Doctor

基　　金：浙江省医药卫生一般研究计划(B类)(2014KYB225);浙江省杭州市萧山区重大科技攻关项目(2014211)

摘　　要：目的分析萧山区变态反应性疾病儿童过敏原阳性率、主要过敏原种类,以针对性预防和治疗。方法采用德国MEDIWISS Analytic Gmb H公司产过敏原检测仪及过敏原诊断试剂盒检测321例儿童血清中总IGE及19种吸入性和食入性过敏原特异性IGE抗体。结果疾病组儿童血清中总IGE阳性率为80.8%(173/214),特异性IGE抗体阳性率为61.2%(131/214)。吸入性过敏原前三位分别为尘螨、屋尘、狗毛皮屑;食入性过敏原前三位分别为牛奶、鸡蛋白、牛肉。不同性别总IGE阳性率及特异性IGE抗体阳性率无显著差异性。<3岁组以食入性过敏原为主,学龄期组以吸入性过敏原为主。变态反应性疾病组过敏原特异性IGE阳性中,一种过敏原阳性率、二种过敏原阳性率、三种及以上过敏原阳性率分别为31.8%(68/214)、27.6%(59/214)、21.5%(46/214)。结论变态反应性疾病儿童血清中总IGE和过敏原特异性IGE阳性率明显高,吸入性过敏原以尘螨为主,食入性过敏原以牛奶为主,三种及以上过敏原阳性率占21.5%(46/214)。变态反应性疾病儿童在春秋二季尤其应避免接触过敏原。Objective To analyze in Xiaoshan allergic diseases of the children＇s positive rate of allergens, main aller gens types, so that targeted prevention and treatment. Methods The serum levels of total IGE and 19 kinds of specificity inhales and food allergens in 321 children were detected by Germany Allergy Screen allergens detection system. Results The total IGE positive rate and specificity IGE positive rate of Allergic diseases group were 80.8%（!73/214） and 61.2% （131/214）. Inhaled allergens were higher for： household dust mites, house dust and dog dander;Food allergens were higher for：milk,egg white, beef. （There was no significant difference between boys and girls in total IGE positive rate and specificity IGE positive rate.） Food allergens were major in 〈3 years children while inhaled allergens were major in 〉6 years children. The respective positive rates of one kind, two kinds and above three kinds were 31.8%（68/214）, 27.6%（59/214）, 21.5%（46/214）. Conclusion The total IGE positive rate and specificity IGE positive rate were signifi- cant higher in children allergic diseases group, inhaled allergens to dust mites and food allergens to milk give priority, above three kinds positive rates were 21.5%（46/214）. Allergic diseases children should avoid contacting allergens espe- cially in spring and fall.

关 键 词：变态反应 过敏原 总IGE 特异性IGE 儿童 

分 类 号：R593.1[医药卫生—内科学]