可视化数字神经分子影像技术评价甲基苯丙胺依赖疗效的价值  

Evaluation of the therapeutic efficacy for methamphetamine dependence through visual digital neural molecular imaging techniques

作　　者：杨红杰[1] 贾少微[1] 胡疏[1] 赵正勤[1] 高宙[1] 

机构地区：[1]北京大学深圳医院核医学科,深圳518036

出　　处：《中华行为医学与脑科学杂志》2016年第4期328-333,共6页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：深圳市科技创新委员会基础研究项目（深科技创新[2013]129号）

摘　　要：目的应用单光子发射计算机断层显像（SPECT）纹状体多巴胺转运体（DAT）影像技术评价甲基苯丙胺（MA）依赖的疗效和修复DA能神经元功能缺陷。方法MA依赖组25例，BPRS评分≥35分。采用自定治疗方案，治疗时间≥6个月。用BPRS减分率作为临床疗效评定。SPECT纹状体DAT显像检查，健康志愿组1次、MA依赖组治疗前后各1次。纹状体DAT影像数据采用视觉和定量分析。结果BPRS减分率显示总有效率为80．O％。SPECT纹状体DAT视觉分析显示，MA依赖组治疗前纹状体DAT不同程度的局限性分布减低或缺损，治疗后双侧纹状体DAT明显增多。定量分析显示，MA依赖组治疗前纹状体的V、m和Ra[分别为（19．26±2．85）cm^3、（20．22±2．99）g和（4．78±0．79）％]明显低于健康对照组V、m和Ra[分别为（35．39±4．42）cm^3、（37．16±4．64）g和（7．93±0．86）％]（P〈0．01），治疗后纹状体的V、m和Ra[分别为（22．80±4．28）cm^3、（23．93±4．49）g和（5．64±0．99）％]皆较治疗前明显增加（P〈0．01）。纹状体DAT改善率为76．0％，低于健康对照组（P〈0．01），与总有效BPRS减分率相比，差异无统计学意义（P〉0．05）。结论应用SPECT纹状体DAT可视化数字神经分子影像学技术，评价MA依赖的治疗方案以及修复DA能神经元功能缺陷的价值是可靠的。Objective To evaluate the therapeutic effects of methamphetamine （MA） dependence and the repairment of DA neuronal function by SPECT corpus striatum DAT visual digital neural molecular imaging techniques. Methods 25 MA dependent patients （BPRS score ≥ 35 ） were treated by self-designed treatment program for more than 6 months. The clinical therapeutic effects were scored with reducing rate of BPRS. MA dependent patients were examined by SPECT corpus striatum DAT imaging before and after treatment,while healthy volunteers were examined only once. The SPECT corpus striatum DAT images were analyzed visually and quantitatively. Results The reducing rate of BPRS showed that the total effective rate was 80.0%. Visual analysis of SPECT corpus striatum DAT images showed that the distribution of DAT in the corpus striatum was regionally reduced or defected in various degrees before treatment, and was significantly increased after treatment. Quantitative analysis showed that the bilateral striatal V （（ 19.26 ± 2.85） cm^3）, m（（20.22±2.99） g） and Ra（4.78±0.79）% ） of MA dependent patients were significantly lower compared with those of the healthy volunteers（ respectively （35.39±4.42）cm^3, （37.16±4.64）g and （7.93_± 0.86） %） （ all P〈0.01 ） before treatment and were significantly improved （P〈 0.0l ） after treatment （ V ： （22.80±4.28）cm^3,m： （23.93±4.49） g and Ra： （5.64±0.99）%） with a 76.0% corpus striatum DAT improvement rate. However, the bilateral striatal V, m and Ra of MA dependent patients after treatment were still lower than those of the healthy volunteers （P〈0.01）. There was no significant difference between the striatal DAT improvement rate and the BPRS reduction rate （P〉 0.05）. Conclusion SPECT corpus striatum DAT visual digital neural molecular imaging techniques are reliable in the evaluation of the treatment programs for MA dependence and the repair of DA neuronal function.

关 键 词：甲基苯丙胺 依赖 单光子发射计算机断层显像 多巴胺转运体 疗效 

分 类 号：R817.4[医药卫生—影像医学与核医学] R749.6[医药卫生—放射医学]